lung stages of morphogenesis
Embyronic phase of lung development
lobar buds develop from the FOREGUT
Cells from the endoderm
Connective tissue - blood/vessels - mesoderm
pseudoglander phase of lung development
branching of airways
primitive segmental bronchi
speacialised cells /cillia/mucous glands
Cannicular phase 16-24 weeks
distal architecture = alveolar sacs, terminal bronchioles
T1/T2 pneuomyctes
24 weeks is the limit of variability for foetus to be born
a. true
b. false
a. true
Saccular phase
bronchioles elongates
more surfactant
alevolar sacs grow/well-formed
Alveolar stage
independently sustain breathing
developed structures
Tracheo-oesophageal fistula
abnormal connection between trachea and oesphagus
needs surgical repair
CPAM - congenital pathway airway malformation
abnormal, non-formed lung tissue
Laryngomalacia
floppy airway
collaspe of larynx
strider 6+ weeks
downs syndrome is associated with what heart abnormality
atrio-ventricle defects
Turners syndrome is associated with
co-arctatin of the aorta
short stature
Nonaans syndrome
pulmonary stenosis
22q11 deletion syndrome
Cardiac malformation
Abnormal faces
Thymic hypoplasia
Cleft palate
Hypo-parathyroidism
22q11 deletion