Major Histocompatibility Complex

Question 1

Most pleomorphic.

Answer 1

Major Histocompatibility Complex

Question 2

Originally referred to as Human Leukocyte Antigens (HLA).

Answer 2

Major Histocompatibility Complex

Question 3

MHC molecule

Answer 3

Major Histocompatibility Complex

Question 4

Found on all nucleated cells in the body.

Answer 4

Major Histocompatibility Complex

Question 5

Produced/synthesized in the rough ER.

Answer 5

Major Histocompatibility Complex

Question 6

To BRING ANTIGEN TO THE CELL SURFACE for recognition by T cells.

Answer 6

Main function: Major Histocompatibility Complex

Question 7

[3] Clinically significance:

Answer 7

1. Transfusion reactions
2. Graft rejections
3. Autoimmune diseases

Question 8

A, B, and C region

Answer 8

Class I genes

Question 9

D region (DR, DQ, DP

Answer 9

Class II genes

Question 10

Not expressed on cell surface: Codes for C4A, C4B, C2, and B proteins, cytokines, such as TNF

Answer 10

Class III

Question 11

Chain structure: α chain, β2 chain

Answer 11

Class I

Question 12

Chain structure: α chain, β chain

Answer 12

Class II

Question 13

Cell distribution: All nucleated cells

Answer 13

Class I

Question 14

Cell distribution: APC & B Cell

Answer 14

Class II

Question 15

Function: Presentation of Antigen to CD8+ T cell

Answer 15

Class I

Question 16

Function: Presentation of Antigen to CD4+ T cell

Answer 16

Class II

Question 17

Endogenous pathway of antigen presentation.

Answer 17

Class I

Question 18

Exogenous pathway of antigen presentation

Answer 18

Class II

Question 19

Nature of peptide binding left: CLOSED at both ends.

Answer 19

Class I

Question 20

Nature of peptide binding left: OPEN at both ends.

Answer 20

Class II

Question 21

INFLAMMATION OF THE VERTEBRAE of the spine.

Answer 21

Ankylosing spondylitis (B27)

Question 22

Diarrhea, weight loss, intolerance to gluten.

Answer 22

Celiac disease (DQ2, DQ8)

Question 23

Inflammation of MULTIPLE JOINTS.

Answer 23

Rheumatoid arthritis (DR4)

Question 24

Increase in blood glucose because of destruction of insulin - producing cells.

Answer 24

Type 1 diabetes (DQ2, DQ8)

Question 25

Responsible for the specificity, diversity, and memory that characterized adaptive immunity.

Answer 25

Lymphocytes

Question 26

Immune response of lymphocytes is triggered by materials called?

Answer 26

Immunogens