Multiple Endocrine Neoplasia Flashcards Preview

Endocrine System > Multiple Endocrine Neoplasia > Flashcards

Flashcards in Multiple Endocrine Neoplasia Deck (7)
Loading flashcards...
1
Q

What is MEN?

A

A group of inherited disorders

They present in the yuonger age group with multifocal hyperplasia/neoplasms of endocrine organs

2
Q

How does MEN 1 occur?

A

Mutation in the Men 1 tumour suppressor gene

  • > Defective menin protein production
  • > Irregular cell growth
3
Q

What are the features of MEN 1?

A
  • Parathyroid Hyperplasia/Adenoma
  • Pancreatic tumours (hypoglycaemia)
  • Duodenal endocrine tumours (hypoglycaemia & ulcers)
  • Pituitary adenomas (mainly prolactinoma)
4
Q

What cause MEN 2?

A

Mutations in RET proto-oncogenes

5
Q

What are the features of basic MEN 2?

A

Medullary Carcinoma of thyroid and pheochromocytoma

6
Q

What are the features of the MEN 2A variant?

A

MEN 2 (medullary carcinoma & pheochromocytoma)

+ Parathyroid hyperplasia

7
Q

What are the features of the MEN 2B variant?

A

MEN 2 (medullary carcinoma and pheochromocytoma)

+ Neuromas of skin, mucous membrane and skeletal abnormalities.

Decks in Endocrine System Class (90):