Multiple System Atrophy

Question 1

What is multiple system atrophy?

Answer 1

• Progressive neurodegenerative disorder
• Combination of symptoms that affect both the autonomic nervous system
  
  • Blood pressure
  • Digestion
  • Movement.

Question 2

What is the classic triad of multiple system atrophy?

Answer 2

• Autonomic dysfunction
• Ataxia
• Parkinsonism

Question 3

What is the initial presentation of MSA?

Answer 3

• Presentation = slowness of movement like Parkinson’s disease in 62%
• Ataxia = 22%
• Erectile dysfunction = 9%

Question 4

What signs and symptoms are seen as it naturally progresses?

Answer 4

As it progresses 1 of the 3 main Triad groups is more prominent.

(Parkinsonism, Autonomic dysfunction, Cerebellar dysnfunction)

Question 5

What are some sign of autonomic dysfunction?

Answer 5

• Postural or orthostatic hypotension.
• Urinary incontinence or urinary retention
• Impotence
• Constipation
• Vcal cord paralysis
• Dry mouth and skin
• Trouble regulating body temperature due to sweating deficiency in all parts of the body