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Flashcards in Neuromuscular Blockers Med Chem Deck (60)
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1

What are the general properties of Spasmolytic agents? (Select All)

A. The exact MOA of spasmolytic medications is not completely known.

B. They are all typically Uncharged and as a result they are orally absorbed and can penetrate the BBB more easily

C. They all exhibit a common pharmacophore (common structure and MOA)

D. Act at the spinal cord and not the brain

E. Have drug interactions with opiod analgesics, benzodiazepines and barbituates and can cause respiratory depresion

A, B, D, E

2

Spasmolytics are centrally acting agents at the spinal cord and can have DDIs with opiod analgesics, barbituates and benzodiazepines. Which of the following statements is true when spasmolytics are used with these agents?

A. Patient must be monitored closely for respiratory depression

B. Dosages will not need to be adjusted from either medication

C. Patients should avoid alcohol and other CNS depressants with spasmolytics

D. Dose reduction may be needed for one or both drugs

A, C, D

3

Baclofen is known as a _____.

A. GABA-A analog

B. GABA-B analog

 

B

4

Which structure of the following statements is true?

I: The structure circled in blue increases lipophilicity

II: The structure circled in green is an amino acid

III: The structure circled in green is Gamma-Aminobutyric Acid (GABA)

A. I only

B. II only

C. II and III

D. I and III

E. I, II, and III

D

5

All of the following statements are true about Baclofen EXCEPT:

A. GABA-B analog

B. GABA-A analog

C. High BBB penetration due to the P-Chloro group 

D. Can be given intrathecally in the case of sever spasms

E. Eliminated unchanged in the urine and as a result its dose must be renally adjusted

B

6

What is the name of the moeity circled in Carisoprodol?

A. Thioethester

B. Alkanediol

C. Glycerol

D. Diesterpropane

B

7

In the drug Carisoprodol what is the name of the moeity circled in red?

A. Ester

B. Amide

C. Carbamate

D. none of the above

C

8

What enzyme is responsible for metabolizng Carisoprodol to it's active metabolite Meprobamate?

A. CYP2C19

B. CYP2C9

C. CYP3A4

D. None of the above

A

9

If CYP2C19 metabolizes Carisoprodol to Meprobamate what what will you see in patients that are poor CYP2C19 metabolizers?

A. Increased levels of Meprobamate

B. Decreased levels of Meprobamate and increased levels of Carisoprodol 

C. Identical levels of meprobamate and carisoprodol

D. No change in metabolism

B

10

What kind of reaction is happening with the metabolism of Carisoprodol to Meprobamate?

A. N-Dealkylation

B. Methylation

C. Ester Hydrolysis

D. None of the above

A

11

Which of the following statements is true regarding Carisoprodol? (Select All)

A. Metabolized by CYP2C9

B. Metabolized by CYP2C19

C. Drug and its metabolite have sedative, anxiolytic effect (Abuse potential)

D. Bioavailability of the drug will be affected by CYP2C19 inhibitors and inducers

B, C, D

 

She has the cyp enzyme and abuse potential in red so its important

12

What is the name of the structural moeity in Chlorzoxazone (Paraflex)?

A. Benzoimide

B. Benzopurine

C. Benzoxazolone

D. None of the above

C

Blue: Benz

Red: Oxazole

Green: ketone="one"

Benzoxazolone

13

Which of the following side effects are seen with Chlorzoxazone (Paraflex)?

A. Idiosyncratic Hepatotoxicity

B. Dermatologic reactions

C. Uticaria, Erythma, Pruritus

D. All of the above

D

14

Cyclobenazaprine HCL (FLexeril, Amrix) has a ____ moeity that makes it similar to _____. 

A. Bicyclic, Bicyclic antidepressants

B. Tricyclic, Tricyclic antidepressants

 

B

15

Which of the following statements is true regarding Cyclobenzaprine HCl (Flexeril, Amrix)?

A. Long Plasma half life of 1-3 days

B. Accumulates on multiple dosing

C. Causes high incidence of sedation

D. All of the above

D

16

Cyclobenzaprine HCl (Flexeril, Amrix) should not be taken with ____ within ____ days of each other

A. MAO inhibitors, 14

B. MAO inhibitors, 7

A

17

T/F Even though Cyclobenzaprine HCl (Flexeril, Amrix) is structurally identical to a tricyclic antidepressant it does not have the efficacy of an antidepressant

T

18

Diazepam (Valium) is a has the ____ structural moeity.

A. Benzodiazepine

B. Benzomonazepine

C. Benzotriazepine

D. None of the above

A. 

Benzo- Benzene ring 

Diaz- meaning two nitrogens

Pine- 7-membered ring

19

When Diazepam is metabolized it creates an ____ drug known as ____.

A. Inactive, Desmethyldiazepam

B. Active, Desmethyldiazepam

B

Des-meaning one less

Desmethyl- meaning one less methyl group

20

The desmethyldiazepam metabolite has a half-life of ___ hours

A. 1 

B. 10

C. 100

D. 1000

C

21

Metaxolone (Skelaxin) has the ___ moeity, just as Carisoprodol has. 

A. Alkanediol

B. Alkanetriol

C. Alkenediol

D. None of the above

A

Alkane-3 carbon chain

Diol- two alcohols

Alkanediol

22

Metaxolone has a very large volume of distribution of ____ L

A. 8

B. 80

C. 800

D. 8000

C

23

T/F Metaxolone causes muscle relaxation without excessive sedation and is NOT associated with abuse

T

24

Metaxolone bioavailability can be increased if taken with ____.

A. Grapefruit juice

B. Fatty foods

C. Low-fat containing foods

D. On an empty stomach

B

25

Methocarbamol (Robaxin) contains the ____ moeity.

A. Glyceroldiether

B. Glyceroltriether

C. Glycerolmonoether

D. Glycerol

C

It has a glycerol backbone but one ether connection (the other is an ester) so it can be called a glycerolmonoether

26

Methocarbamol (Robaxin) should be used with caution in patietns that have____

A. Parkinsons

B. Myasthenia gravis

C. Multiple Sclerosis 

D. Flaccid paralysis

B

27

Orphenadrine Citrate (Norflex) contains the ____ moeity. 

A. Ethanolamine ether

B. Ethanolamine Ester

C. Propanolamine ether

D. Propanolamine Ester

A

Ethan- Two carbons (on the right of the oxygen)

Ol- Oxygen in the middle

Amine- Nitrogen on the right

Ether- ether in the middle

Ethanolamine ether

28

T/F Orphenadrine Citrate (Norflex) resembles an H1 antagonist Diphenhydramine HCl

T

29

Tizanidine (Zanaflex) is structurally similar to clonidine. Because of this it can exhibit ____effects.

A. Hypertensive

B. Hypotensive

B

30

(Information Slide) The structure shown here is acetyl choline and certain paralytic drugs will contain this structure.