oncologic emergencies and GI toxicity Flashcards Preview

PT3 Oncology > oncologic emergencies and GI toxicity > Flashcards

Flashcards in oncologic emergencies and GI toxicity Deck (35):
1

4 types of cancer induced nausea and vomiting

anticipatory
acute
delayed
breakthrough/refractory

2

risk factors for CINV

-female
-younger
-poor emetic control in previous cycles
-Hx of motion sickness
-Hx of morning sickness

3

ondansetron MoA

inhibits serotonin receptors

4

ondansetron adverse effects

headache
constipation
diarrhea
QT prolongation

5

ondansetron phase use

acute
delayed

6

aprepitant MoA

inhibit NK1 receptors

7

apreptiant adverse effects

fatigue
dizziness
diarrhea

8

apreptiant phase use

acute
delayed

9

phenothiazine drugs

prochlorperazine
promethazine

10

phenothiazines MoA

inhibit D2 receptors

11

phenothiazines adverse effects

CNS depression
anticholinergic
extrapyramidal symptoms
hypotension

12

benzamide drug

metoclopramide

13

metoclopramide MoA

inhibit D2 and serotonin

14

metoclopramide adverse effects

sedation
diarrhea
EPS
QT prolongation

15

metoclopramide phase use

breakthrough/refractory

16

phenothiazine phase use

acute
delayed
breakthrough

17

atypical antipsychotic for N/V

olanzapine

18

olanzapine MoA

inhibit dopamine and serotonin

19

olanzapine adverse effects

somnolence
dry mouth
dizziness
QT prolongation

20

olanzapine phase use

acute
delayed
refractory

21

corticosteroid of choice for NV

dexamethasone

22

dexamethasone phase use

acute
delayed

23

benzodiazepine of choice for NV

lorazepam

24

lorazepam phase use

anticipatory
breakthrough

25

cannabinoids phase use

breakthrough/refractory

26

cannabinoids adverse effects

anticholinergic
sedation
appetite stimulation
hallucinations

27

general prophylaxis treatment for high risk NV

5HT3 + dexameth + aprepitant +- olanzapine

28

general prophylaxis treatment for moderate risk NV

5HT3 + dexameth +- aprepitant

29

general prophylaxis treatment for low risk NV

5HT3 or steroid or phenothiazone

30

treatment for mucositis

-mouthwash and coating agents
-analgesics
-corticosteroids

31

treatment of diarrhea

-hydration
-BRAT diet and clear liquids
-loperamide, octreotide

32

treatment of constipation

-stop nonessential meds
-increase fluids
-any laxitive

33

signs and symptoms of hypercalcemia

-fatigue and altered mental status
-AKI
-NV, anorexia, PUD
-short QT, ventricular arrhythmia

34

Risk factors for tumor lysis syndrome

-highly proliferative
-malignancies
-high treatment sensitivity
-renal dysfunction

35

management of spinal cord compression

-dexamethasone 10-100 mg bolus, 4-8 q6h
-spinal radiation
-surgery
-chemo
-pain management