OVERVIEW OF LIVER DISEASE AND LIVER FUNCTION TESTS Flashcards Preview

GASTRO-INTESTINAL MEDICINE AND HEPATOLOGY > OVERVIEW OF LIVER DISEASE AND LIVER FUNCTION TESTS > Flashcards

Flashcards in OVERVIEW OF LIVER DISEASE AND LIVER FUNCTION TESTS Deck (80)
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61

In an acute bout of ischaemic liver injury, what will liver function tests reveal?

Huge elevation in ALT very sudden
Huge elevation in AST
Increased INR

62

How will liver function tests of someone with chronic hepatitis B differ from someone with an acute infection of hepatitis B?

They will be similar but ALT and AST won't be as raised in the chronic case.
There will most likely be an increased INR in the chronic case
Albumin may be low in the chronic case

63

How will liver function tests of someone with chronic hepatitis C differ from someone with an acute infection of hepatitis C?

They will be similar but ALT and AST won't be as raised in the chronic case.
There will most likely be an increased INR in the chronic case
Albumin may be low in the chronic case

64

In someone suffering from non-alcohol steatohepatitis (NASH/fatty liver disease), what will liver function tests reveal?

Increased ALT
Increased AST
ALT increased more than AST
Low albumin

65

In someone suffering from alcoholic liver disease, what will liver function tests reveal?

Increased AST
Increased ALT
AST increased more than ALT
Low albumin

66

In someone suffering from autoimmune hepatitis, what will liver function tests reveal?

Increased ALT
Increased AST
ALT increased more than AST
Low albumin

67

What do we look for in the blood in order to make a diagnosis of autoimmune hepatitis?

Anti-smooth muscle antibody

68

In someone suffering from hereditary haemochromatosis, what will liver function tests reveal?

Increased ALT
Increased AST
Low albumin

69

What do we look for in the blood in order to make a diagnosis of haemochromatosis?

Serum ferritin > 1000
Low or normal Total iron binding capacity

70

What is hereditary haemochromatosis?

An autosomal recessive genetic disease (found on chromosome 6) in which increased intestinal absorption of iron causes accumulation in tissues, especially the liver, which may lead to organ damage. Other organs that may be affected by iron deposits include the pancreas, joints, heart, skin and gonads.

71

In someone suffering from Wilson's disease, what will liver function tests reveal?

Increased ALT
Increased AST
Low albumin
Low ALP

72

What sign seen on examination might indicate that someone has Wilson's disease?

Kayser-Fleischa rings in their eyes

73

What do we look for in the blood in order to make a diagnosis of Wilson's disease?

Low ceruloplasmin
Low ALP

74

In someone suffering from alpha 1 antitrypsin deficiency, what will liver function tests reveal?

Slightly increased ALT
Slightly increased AST

75

What will be seen in a histological assessment of liver biopsy in someone with liver disease as a result of alpha 1 antitrypsin deficiency?

PAS positive granules

76

What do we look for in the blood in order to make a diagnosis of alpha 1 antitrypsin deficiency?

Low levels of alpha-1AT

77

In someone suffering from primary biliary cirrhosis, what will liver function tests reveal?

Increased ALP
Increased bilirubin (but later in the disease)

78

In someone suffering from primary sclerosing cholangitis, what will liver function tests reveal?

Increased ALP
Increased bilirubin

79

In someone suffering from large bile duct obstruction, what will liver function tests reveal?

Increased ALP
Increased bilirubin

80

What is the classic history of a patient with large bile duct obstruction?

Pain
Fever
Jaundice