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Flashcards in Part 2 Deck (60)
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1

In systemic arteries, a small change in volume is associated with a?

Large change in pressure

2

In systemic veins, a large change in volume is associated with a?

Small change in pressure

3

What is 8x more distensible and 24x more compliant than systemic arteries?

Veins

4

Increased pressure tightens?

Wall Tone

5

Decreased pressure loosens?

Wall Tone

6

What causes osscilating pressure?

Change in blood volume

7

Local blood flow is regulated in proportion to the?

Metabolic Demand in most tissues

8

Short term control of blood flow involves vasodilation and vasoconstriction of?

Pre-capillary Resistent Vessels

9

Long term control of blood flow involves?

Changes in tissue vascularity

10

Changes in tissue vascularity includes?

1. Formation/Dissolution of Blood Vessels
2. Vascular Endothelial Growth Factor and Angiogenin

11

What acts as an integrator of multiple inputs?

Arterioles

12

Arterioles are richly innervated by SNS vasoconstrictor fibers and have?

Alpha Receptors

13

Arterioles are effected by local factors which include?

Vasodilators
Circulating Substances

14

Local vasodilators include?

Nitric Oxide
Carbon Monoxide
Oxygen
Adenosine
Potassium Ions
Hydrogen Ions
PGE and PGI

15

With vasodilation decreased resistance will?

Increase Flow

16

With vasoconstriction increased resistance will?

Decrease Flow

17

As tissue uses up oxygen, vascular smooth muscle cannot maintain constriction. This is known as?

Oxygen Demand Theory

18

The ability to keep blood flow constant in the face of a changing arterial BP is called?

Autoregulation

19

Most tissues show some degree of?

Autoregulation

20

In the kidney, both renal flow and glomerular filtration rate (GFR) are?

Autoregulated

21

Long term control of flow involves changes in?

Tissue Vascularity

22

What is the production of new micro vessels?

Angiogenesis

23

Shear stress caused by enhanced blood flow velocity associated with partial occlusion is called?

Arteriogenesis

24

Angiogenic factors are small peptides that stimulate?

Growth of new vessels

25

Angiogenic factors were first isolated from?

Tumors

26

Stress activated endothelium up-regulates the expression of?

Monocyte Chemoattractant Protein-1 (MCP-1)

27

MCP-1 attract proteins that?

Invade Arterioles

28

Other adhesion molecules and growth factors participate with MCP-1 during?

Inflammation
Cell Death

29

Hypoxia causes the release of?

VEGF

30

Enhanced production of VEGF is partly mediated by?

Adenosine in response to hypoxia