Pneumoconiases

Question 1

pneumoconioses - types

Answer 1

1. asbestosis
2. Berylliosis
3. Coal workers’ pneumoconiosis
4. silicosis

Question 2

pneumoconioses (except berylliosi) - increased risk for

Answer 2

1. cor pulmonale
2. Caplan syndrome
3. cancer

Question 3

Caplan syndrome

Answer 3

rheumatoid arthritis and pneumoconiases (coal, asbestosis, silicosis) with intrapulmonary nodules

Question 4

Asbestosis is associated with (exposure)

Answer 4

1. shipbuilding
2. roofing
3. plumbing

Question 5

pathognomonic lesions of asbestosis (gross)

Answer 5

Ivory white, calcified supreadiaphragmatic and pleural plaques

Question 6

areas of asbestos plaques

Answer 6

1. supreadiaphragmatic

2. pleural plaques

Question 7

carcinomas associated with asbestosis

Answer 7

1. bronchogenic carcinoma

2. mesothelioma

Question 8

asbestosis - bronchogenic ca vs mesothelioma

Answer 8

bronchogenic ca > mesothelioma

Question 9

asbestosis affect (area)

Answer 9

lower lobes

Question 10

berylliosis associated with (exposure)

Answer 10

berryllium in

1. aerospace
2. manufacturing industries

Question 11

lung Asbestosis - histology

Answer 11

ferruginous (asbestos) bodies: golden-brown fusiform rods resembling dumbbells, found in alveolar septum (visulized using PAS stain), often obtain by branchoalveolar lavage)

Question 12

ferruginous bodies are found in

Answer 12

alveolar septum

Question 13

berylliosis affects (area)

Answer 13

upper lobes

Question 14

berrylliosis histology

Answer 14

noncaseating granoulomas in lung, hilar lymph nodes and systemic organs

Question 15

berrylliosis treatment

Answer 15

occasionally responsive to steroids

Question 16

Coal workers’ pneumoconiosis is also known s

Answer 16

black lung disease

Question 17

Coal workers’ pneumoconiosis affects (area)

Answer 17

upper lobes

Question 18

Coal workers’ pneumoconiosis - pathophysiology

Answer 18

prolonged coal dust exposure –> macrophages laden with carbon –> inflammation and fibrosis

Question 19

Anthracosis is caused by

Answer 19

mild exposure to carbon (collection of macrophages laden with carbon)

Question 20

Anthracosis - symptoms/dound in

Answer 20

asymptomatic condition found in many urban dwellers exposed to sooty air

Question 21

Anthracosis - occupation

Answer 21

found in many urban dwellers exposed to sooty air

Question 22

Silicosis is associated with ….(occupation)

Answer 22

1. foundries (factory that produces metal castings)
2. sandblasting
3. Mines

Question 23

Silicosis - pathophysiology

Answer 23

Macrophages respond to silica and release fibrogenic factors, leading to fibrosis. it is thought that silica may disrupt phagolysosomes and impair macrophages

Question 24

silicosis - increased risk for

Answer 24

1. TB

2. bronchogenic carcinoma

Question 25

silicosis affects (area)

Answer 25

upper lobes

Question 26

silicosis - CXR

Answer 26

Eggshell calcification of hilar lymph nodes

Question 27

pneumoconiases that affect upper lobes

Answer 27

1. coal workers' pneumoconiosis 2. Silicosi 3. Berylliosis

Question 28

pneumoconiases that affect lower lobes

Answer 28

asbestosis

Question 29

pneumoconiases - increased risk for TB

Answer 29

silicosis

Question 30

silicosis histology

Answer 30

fibrotic nodules found in upper lobes

Question 31

asbestosis histology

Answer 31

fibrosis of lung and pleura (plaques)

Question 32

pneumoconiases - roofing

Answer 32

asbestosis

Question 33

pneumoconiases - eggshell appearance

Answer 33

silicosis

Question 34

pneumoconiases - black lung disease

Answer 34

Coal workers' pneumoconiosis

Question 35

pneumoconiases - ferruginous bodies

Answer 35

asbestosis

Question 36

pneumoconiases - fibrosis

Answer 36

1. asbestosis 2. Coal workers' pneumoconiosis 3. silicosis

Question 37

pneumoconiases - respond to steroids

Answer 37

Berylliosis (occasionally responsive)

Question 38

rheumatoid arthritis and pneumonoconioses with intrapulmonary nodules = ?

Answer 38

Caplan disease

Question 39

pneumoconiases - disrupts phagolysosomes

Answer 39

silicosis

Question 40

pneumoconiases - types and affected area of lung

Answer 40

1. asbestosis --> lower lobes 2. Berylliosis --> upper lobes 3. Coal workers' pneumoconiosis --> upper lobes 4. silicosis --> upper lobes

Question 41

Ferruginous bodies are visualized using

Answer 41

Prussian blue stain

Question 42

Asbestosis also increases the risk of

Answer 42

Pleural effusions