Progesterone

Question 1

Name natural and synthetic progestins

Answer 1

Natural:
1. Progesterone
Synthetic:
1. Medroxyprogesterone acetate
2. hydroxyprogesterone caproate
3. Megestrol acetate
4. Norethindrone
5. norgestrel
6. Levonorgestrel
7. desogestrel
8. norgestimate
9. Gestodene

Question 2

Which progestin drugs Have potent anti-ovulatory effect

Answer 2

1. Desogestrel
2. norgestrel
3. Gestodene

Question 3

What are the uses of progestin

Answer 3

1. Contraception
2. dysfunctional uterine bleeding
3. endometriosis
4. hormone replacement therapy in menopausal woman
5. endometrial carcinoma
6. postponement of periods

Question 4

What are the adverse effects of progestin

Answer 4

1. Fluid retention
2. acne, depression, weight gain
3. Hirsutism
4. irregular periods
5. increase blood glucose level
6. increased risk of breast cancer

Question 5

Name a competitive antagonist of progesterone that has leutolytic Properties and anti-glucocorticoid and anti-androgenic activity

Answer 5

Mefipristone

Question 6

What are the uses of mifepristone

Answer 6

1. Termination of pregnancy
2. contraception
3. induction of labour in case of intrauterine fetal death
4. cervical ripening before abortion or induction of labour

Question 7

What are the adverse effects of mifepristone

Answer 7

1. Nausea, vomiting coming diarrhea, abdominal pain, headache
2. uterine bleeding
3. teratogenicity

Question 8

Which drug can be used as a postcoital contraceptive by causing sloughing and shedding of decidua

Answer 8

Mefipristone

Question 9

Which drugs decrease oestrogen levels by inhibiting aromatase enzyme

Answer 9

1. Letrozole
2. anastrozole
3. Exemestane