1
Q
Classify androgens
A
- Natural androgens - testosterone dihydrotestosterone, dehydroepiandrosterone, androstenedione
- Synthetic androgens - Methyltestosterone, fluoxymesterone
- Esters of testosterone - cypionate, enanthate, undecanoate
2
Q
What are the functions of testosterone
A
- Male secondary sexual characteristics
- maturation of reproductive organs
- increase in mass and strength of skeletal muscle
- erythropoiesis
3
Q
What are the adverse effects of testosterone
A
- In women - hirsuitism, menstrual irregularities, breast trophy, acne and deeping invoice
- children impairment of growth - premature closure of epiphisis
- Sodium and water attention leading to oedema
- cholestatic jaundice
4
Q
Which drug causes cholestatic jaundice
A
Methyltestosterone
5
Q
What are the uses of testosterone
A
- Replacement therapy in men with hypogonadism
- HIV patients with low testosterone
- senile osteoporosis in men
6
Q
What are the contraindications and precautions of testosterone
A
- Pregnancy
- carcinoma prostate in breast cancer in men
- Renal in cardiac disease
7
Q
Name anabolic steroids/synthetic androgens
A
- Nandrolone phenylpropionate
- Nandrolone decanoate
- Oxandrolone
- Stanozolol
- Ethylestrenol
- Methandienone
8
Q
What are the uses of synthetic androgens
A
- Improve appetite and feeling of well being
- recovery of prolonged illness, surgery, burns, trauma
- post menopausal and senile osteoporosis
- control itching of chronic bilary obstruction
9
Q
Classify antiandrogens
A
- Physiological antagonist: oestrogen
- Testosterone synthesis inhibitors: keyoconazole, spironolactone
- receptor antagonist: flutamide, bicalutamide, cyproterone, spironolactone
- 5 alpha inhibitors: finasteride, dutasteride

10
Q
Which antiandrogen to be used to treatment for benign prosthetic hyperplasia
A
Finasteride
Dutasteride
Pharamcology Endocrine
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