1
Q
M2 MOA
A
Gi/Go–>inhibits AC–>decrease cAMP–> activation of K+ channels–>Ca channel hyperpolarization and inhibition
2
Q
M2 effect on SA node
A
slows spontaneous depolarization
decreases HR
3
Q
M2 effect on AV node conduction
A
decrease
4
Q
M2 effect on atrium
A
increases refractory period
decreases contraction
5
Q
M2 effect on Ventricle
A
slight decrease in contraction
6
Q
M2 effect on Smooth muscle
A
contraction
7
Q
M2 effect on peripheral nerves
A
inhibition via auto/heteroreceptors (decreases ganglionic transmission)
8
Q
M3 and M5 MOA
A
Gq–>PLC–>IP3 and DAG–> increase in Ca and PKC–>depolarization and excitation
**Synthesis of NO!!!
Decks in class (2)
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