What is shock?
A syndrome characterized by decreased tissue perfusion and impaired cellular metabolism, causing an imbalance between oxygen/nutrient supply and demand.
What happens during shock at the cellular level?
Hypoperfusion → increased O₂/nutrient demand → ischemia → cell injury → cell death.
What are the main classifications of shock?
Cardiogenic, Hypovolemic, Distributive (Anaphylactic, Septic, Neurogenic), and Obstructive.
What is the pathophysiology of cardiogenic shock?
Systolic or diastolic dysfunction of the heart → decreased cardiac output (CO), stroke volume (SV), and BP → poor tissue perfusion.
What is the leading cause of cardiogenic shock?
Myocardial infarction (MI).
What are causes of cardiogenic shock?
Cardiac tamponade, ventricular hypertrophy, cardiomyopathy, dysrhythmias (brady/tachy), valvular stenosis or regurgitation, ventricular septal rupture, tension pneumothorax, MI.
What are key patient presentations in cardiogenic shock?
Tachycardia, hypotension, narrow pulse pressure, delayed cap refill.
What are assessment findings in cardiogenic shock?
Tachypnea, crackles, cyanosis, pallor, weak pulses, cool/clammy skin, decreased urine output, anxiety, confusion, agitation.
What is the goal of treatment in cardiogenic shock?
Restore heart function and balance oxygen supply and demand.
What are key treatments for cardiogenic shock?
Revascularization (angioplasty/stent), valve replacement, intra-aortic balloon pump, ventricular assist device (VAD).
What are the main drug therapies used for cardiogenic shock?
What is the definition of hypovolemic shock?
Inadequate intravascular fluid volume to support perfusion.
What is absolute hypovolemia?
Actual fluid loss from the body (e.g., hemorrhage, vomiting, diarrhea, fistula drainage, diabetes insipidus, diuresis).
What is relative hypovolemia?
Fluid shifting out of the vascular space (e.g., third spacing, internal bleeding, bowel obstruction, massive vasodilation).
What are causes of hypovolemic shock?
External blood/fluid loss, internal bleeding, third spacing, massive vasodilation, fluid shifts.
How much blood loss can the body compensate for before showing signs of shock?
Up to 750 mL (≈15% of total volume).
What are early patient presentations in hypovolemic shock?
Tachycardia, cool/clammy/pale skin, decreased cap refill, absent bowel sounds, anxiety, confusion, agitation, decreased urine output.
What are late signs of hypovolemic shock?
Bradycardia and severe hypotension.
Why are bowel sounds absent in hypovolemic shock?
Because of shunting of blood to vital organs, reducing GI perfusion.
What lab studies are important in hypovolemic shock?
Hemoglobin, hematocrit, electrolytes, lactate, blood gases, urine output.
What does an elevated lactate level indicate?
Poor tissue perfusion and anaerobic metabolism.
What is the goal of hypovolemic shock treatment?
Restore tissue perfusion.
What type of IV access is used for rapid fluid replacement?
1–2 large-bore IVs, intraosseous device, or central venous catheter.
What fluids are commonly used initially for resuscitation?
Normal Saline (NS) or Lactated Ringers (LR).