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Nelson - Rheumatic Diseases of Childhood > SLE > Flashcards

Flashcards in SLE Deck (16):
1

Joint inflammation due to a sterile inflammatory reaction following a recent infection

Female

2

Histopathologic features most suggestive of SLE

1) Renal findings 2) Skin findings, especially discoid rash

3

Deposition of immune complexes within the dermal-epidermal junction specific for SLE

Lupus band test

4

Hallmark of SLE

Generation of autoantibodies against self-antigens

5

Immune cells that demonstrate functional impairments in SLE

B and T cells

6

MC presenting complaints of children with SLE

Fever, fatigue, hematologic abnormalities, arthralgia, arthritis

7

Presence of 4 out of 11 of ___ simultaneously or cumulatively establishes the diagnosis of SLE

ACR 1997 Revised Classification Criteria for SLE

8

ACR 1997 Revised Classification Criteria for SLE

SOAP BRAIN MD: Serositis, Oral ulcers, Arthritis, Photosensitivity, Blood (hemolytic anemia, leukopenia, lymphopenia, thrombocytopenia), Renal, ANA, Immunologic abnormalities, Neurologic (seizure/psychosis), Malar rash, Discoid rash

9

Immunologic abnormalities in SLE

POSITIVE: Anti-dsDNA, anti-Sm, lupus anticoagulant, ANA; False positive RPR, Elevated anticardiolipin

10

Elevated in drug-induced SLE

Anti-histone antibodies

11

Antibodies specific for SLE

Anti-dsDNA

12

Antibody seen in SLE that correlates with disease activity

Anti-dsDNA

13

Anti-dsDNA correlates with SLE disease activity, particularly

Nephritis

14

Mainstay of treatment for significant manifestations of SLE

Corticosteroids

15

MCC of death in individuals with SLE in the first several years of diagnosis

1) Infection 2) Complications of GN 3) Neuropsychiatric disease

16

MCC of death in individuals with SLE over the long term

Complications of atherosclerosis and malignancy