Trigger 2

Question 1

3 main constitutents of circle of willis

Answer 1

• anterior cerebal artery
• middle cerebral artery
• posterior cerebral artery

Question 2

Effect of depolarisation on NMDA R

Answer 2

• postitive charge repels Mg2+ therefore removed

- allows Ca2+ influx

Question 3

Why is more ROS generated in reperfusion injury?

Answer 3

O2 restored so more ROS can be formed

Question 4

Genes transcribed by HIF

Answer 4

• EPO
• VEGF
• angiogenesis genes
• eNOS
• iNOS

Question 5

Steps in atherosclerosis formation

Answer 5

1. endothelial dysfunction
2. stable plaque formation
3. t cell activation
4. plaque rupture and clotting

Question 6

What are the 2 gold standard cardiac markers for MI tests?

Answer 6

high sensitivity cardiac specific troponin I/T

- expressed from diff genes to skeletal muscle

Question 7

What activates the extrinsic pathway?

Answer 7

Tissue factor release

• acts as R for factor 7
• which binds in presence of phospholipids and Ca2+
• activates factor 10 in presence of phospholipids and Ca2+

Question 8

Give 2 examples of tpa like drugs

Answer 8

• clot busters

- altepase and streptokinase