Tuberculosis Flashcards Preview

1MB Respiratory > Tuberculosis > Flashcards

Flashcards in Tuberculosis Deck (14)
Loading flashcards...
1
Q

Which bacteria is the commonest cause of TB?

A

Mycobacterium tuberculosis

2
Q

What is the primary test for TB?

A

PCR

3
Q

TB involves non-caseating necrosis. True/False?

A

False

It is caseating

4
Q

What is interferon gamma testing re TB?

A

Measures how much IFG is released from T cells in response to stimuli (MTB)

5
Q

Which 4 drugs are used for TB?

A

Rifampicin
Isoniazide
Pyrazinamide
Ethambutol

6
Q

Start of with 4 months on RI, then 2 months on PE. True/False?

A

False

2 months on RIPE, then 4 months on RI

7
Q

If patient has TB affecting CNS, what is the treatment course?

A

2 months on RIPE, then 10 months on RI

8
Q

List some adverse reactions of Rifampicin

A

Hepatitis
Orange-red urine
Flu syndrome

9
Q

List some adverse reactions of Isoniazide

A

Hepatitis

Peripheral neuropathy

10
Q

List some adverse reactions of Pyrazinamide

A

Hepatitis
Anorexia, vomiting
Hyperuricaemia

11
Q

List some adverse reactions of Ethambutol

A

Colour blindness, developing into blindness

Arthralgia

12
Q

What proportion of the world population is affected by TB?

A

1/3

13
Q

Which components make up the necrosis in TB?

A

Epitheloid cells and Langhan’s giant cells, causing formation of Ghon focus

14
Q

When might the Mantoux/tuberculin skin test for TB be false negative?

A

If patient has had a BCG vaccination