02a: Cervical Flashcards Preview

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Flashcards in 02a: Cervical Deck (20):
1

Squamous cell carcinoma of cervix peAk incidence at what age?

40-45

2

Cervical LSIL (low grade squamous intraepithelial lesion): what are the chances the lesion will regress, persist, and progress to HSIL?

Regress: 60%
Persist: 30%
Progress: 10%

3

Cervical HSIL (high grade squamous intraepithelial lesion): what are the chances the lesion will regress, persist, and progress to carcinoma?

Regress: 30%
Persist: 60%
Progress: 10%

4

T/F: in both malignant and benign HPV lesions, the virus integrates into host DNA.

False - integration important in malignancy

BUT in benign warts/paraneoplastic lesions, virus is free

5

Which drugs/substances increase risk of cervical cancer?

Oral contraceptives and nicotine

6

Pap smear: metabolically inactive cells are stained (X). Metaplastic squamous cells stained (Y)

X = pink
Y = blue green

7

Women with normal pap and negative HPV DNA should be screened again every:

3 years

8

Women with normal pap and positive high risk HPV DNA should be screened again every:

Rescreen again at 6-12 mo

9

Cervical cancer staging: stage 0

CIN (cervical intraepithelial neoplasia) 3 (full thickness of epithelium)

10

Cervical cancer staging: stage 1

Carcinoma (breached BM) confined to cervix

11

Cervical cancer staging: stage 2

Tumor extends beyond cervix (not onto pelvic wall) and into vag but not lower 1/3

12

Cervical cancer staging: stage 3

Involves pelvic wall or lower 1/3 of vag; regional node metastasis

13

Cervical cancer staging: stage 4

Beyond true pelvis, mucosa of bladder/rectum and/or metastasis

14

Bethesda System establish to report (X)

X = Pap smears

15

Cervical cancer: 5y survival for stage III is (X). And stage IV is (Y)

X = Y = under 50%

16

Cytopathology is study of (normal/abnormal) (X) cells in tissue fluid.

Both normal and abnormal
X = exfoliated (shed)

17

Give examples of natural spontaneous exfoliation of tissue used in cytopathology

1. Skin, vag/cervix
2. Gland secretion (ex: nipple)
3. Sputum
4. Urine

18

T/F: exudates and transudates can be evaluated by cytopathology

True (pleural, pericardial, peritoneal, joint, CSF)

19

T/f: scraping cells from cervix, oral cavity, skin is considered natural spontaneous exfoliation for cytopathology

False - artificially enhanced exfoliation

20

List disadvantages of cytopathology

1. Interpret of cell morphology based only on individual cell observation
2. Can’t always diagnose - may need histo confirmation
3. Doesn’t always determine size/type of lesion