Flashcards in 02a: Cervical Deck (20):
Squamous cell carcinoma of cervix peAk incidence at what age?
Cervical LSIL (low grade squamous intraepithelial lesion): what are the chances the lesion will regress, persist, and progress to HSIL?
Cervical HSIL (high grade squamous intraepithelial lesion): what are the chances the lesion will regress, persist, and progress to carcinoma?
T/F: in both malignant and benign HPV lesions, the virus integrates into host DNA.
False - integration important in malignancy
BUT in benign warts/paraneoplastic lesions, virus is free
Which drugs/substances increase risk of cervical cancer?
Oral contraceptives and nicotine
Pap smear: metabolically inactive cells are stained (X). Metaplastic squamous cells stained (Y)
X = pink
Y = blue green
Women with normal pap and negative HPV DNA should be screened again every:
Women with normal pap and positive high risk HPV DNA should be screened again every:
Rescreen again at 6-12 mo
Cervical cancer staging: stage 0
CIN (cervical intraepithelial neoplasia) 3 (full thickness of epithelium)
Cervical cancer staging: stage 1
Carcinoma (breached BM) confined to cervix
Cervical cancer staging: stage 2
Tumor extends beyond cervix (not onto pelvic wall) and into vag but not lower 1/3
Cervical cancer staging: stage 3
Involves pelvic wall or lower 1/3 of vag; regional node metastasis
Cervical cancer staging: stage 4
Beyond true pelvis, mucosa of bladder/rectum and/or metastasis
Bethesda System establish to report (X)
X = Pap smears
Cervical cancer: 5y survival for stage III is (X). And stage IV is (Y)
X = Y = under 50%
Cytopathology is study of (normal/abnormal) (X) cells in tissue fluid.
Both normal and abnormal
X = exfoliated (shed)
Give examples of natural spontaneous exfoliation of tissue used in cytopathology
1. Skin, vag/cervix
2. Gland secretion (ex: nipple)
T/F: exudates and transudates can be evaluated by cytopathology
True (pleural, pericardial, peritoneal, joint, CSF)
T/f: scraping cells from cervix, oral cavity, skin is considered natural spontaneous exfoliation for cytopathology
False - artificially enhanced exfoliation