02b: Lung Flashcards Preview

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Flashcards in 02b: Lung Deck (26):
1

LDCT screening for lung cancer has high false (pos/neg) rate.

Pos

2

T/F: in study comparing CXR and LDCT for lung cancer screening, there was an immediate increase in lung cancer diagnosis with LDCT.

True

3

T/F: in study comparing CXR and LDCT for lung cancer screening, there was an immediate decrease in lung cancer deaths with LDCT.

False - not immediate (2y lag)

But CT screening reduces lung cancer mortality by 20%

4

Gene mutations in which two oncogenes play big role in adenocarcinomas of lung?

KRAS (35%) and EGFR (15%)

5

Patients with NSCLC (lung cancer) are treated based on:

The specific oncogenic mutations/drivers (KRAS, EGFR, ALK, ROS)

6

Most lung adenocarcinomas are located (centrally/peripherally) and follow (typical/atypical) (X) pattern.

Peripherally

Typical
X = acinar (with glandular differentiation)

7

NSCLC: histology shows large, irregular, peripheral nuclei and some highly eosinophilic cytoplasm, indicating (X). Which specific type of cancer?

X = keratinization

Squamous cell carcinoma

8

New p40 market is positive for (X) lung cancer with 100% sensitivity and 98% specificity

X = squamous cell carcinoma

9

Lung cancer (SCLC) usually present as (central/peripherally) tumors and most patients are (symptomatic/asymptomatic) at presentation.

Central
Symptomatic

10

SVC syndrome symptoms

1. Neck/ arm swelling
2. Distended brings over neck
3. SOB, HA, hoarseness

11

Symptoms related to hepatic metastasis of lung cancer

Weight loss, weakness

12

Symptoms related to brain metastasis of lung cancer

HA, N/V, seizures, personality change, confusion

13

Symptoms related to bone metastasis of lung cancer

Bone pain

14

T/F: paraneoplastic syndromes are signs of metastasis

False - bio active substances secreted by or in response to tumor

15

Humeral hypercalcemia of Malignancy results due to secretin of (X) by which type of lung cancer?

X = PTHrP

Squamous cell carcinoma

16

Hypertrophic osteoarthropathy is paraneoplastic syndrome seen in which lung cancers? What are the symptoms?

Adenocarcinomas

Hand/leg pain, new bone formation, clubbing

17

List the paraneoplastic syndromes seen in SCLC

1. SIADH
2. Lambert-Eaton Syndrome
3. Cushing (ectopic ACTH)

18

Stage I NSCLC treatment

Surg resection

19

Stage II NSCLC treatment

Surg resection + adjuvant chemo

20

Stage IIIA NSCLC treatment

Surg + adjuvant chemo or chemo radiation

21

Stage IIIB NSCLC treatment

Chemo and radiation

22

Stage IV NSCLC treatment

Palliative chemo and maybe radiation

23

All SCLC stages treated the same depending on:

Whether it’s a limited or extensive stage

24

SCLC “limited stage” criteria and treatment

Tumor confined to one area of the chest

Radiation and chemo simultaneously

25

SCLC “extensive stage” criteria and treatment

Not confined to one area of chest

Chemo alone

26

If chemo and radiation causes (X) lung tumor to disappear, preventative (Y) Rx should be given to prevent common brain metastasis

X = SCLC
Y = radiation