Flashcards in 03b: Bone/Soft Tissue Deck (27)
(X) tumor: round to oval sessile masses projecting from the sub-periosteal surface of the bone cortex. Most commonly seen in the (Y) bones of (young/old) patients.
X = osteoma
Y = skull/facial
Osteomas are (slow/fast)-growing tumors. Multiple osteomas are seen in (X) disease.
Slow (little consequences except for mass effect from growth);
X = Gardner Syndrome (a variant of FAP)
Excluding bone marrow tumors (myeloma/lymphoma), what's the most common primary malignant bone tumor?
Osteosarcoma: tumor cells actively (produce/degrade) (X). Seen most commonly in (young/old) patients.
X = bone matrix
Very young (under 20 y.o.) and elderly
Osteosarcoma: tumor usually arises from (epiphysis/metaphysis/diaphysis) of (short/long) bones, especially around which joint?
T/F: Osteosarcomas behave aggressively with a tendency to metastasize.
Benign tumors of hyaline cartilage.
Most common intraosseous cartilage tumor. Usually diagnosed in (young/old) patients.
Multiple enchondromas are seen in (X) Disease or in (Y) disease, if associated with hemangiomas.
X = Ollier
Y = Maffucci Syndrome
Enchondromas are usually (small/large) in size, (symptomatic/asymptomatic), and treated with (X).
Small (under 3 cm);
X = observation or curettage
List the first and second most common matrix-producing malignant bone tumors.
Chondrosarcoma typically grows in which part of skeleton? It's clinically (symptomatic/asymptomatic).
Symptomatic (painful, enlarging mass)
Second most common group of bone sarcomas in kids:
(first is osteosarcoma)
Ewing sarcoma: chromosomal translocation involving (X) gene on which chromosome?
X = EWS
Malignant soft tissue lesions in general, tend to be very (nonaggressive/aggressive) tumors. They have a propensity to metastasize to (X).
X = lungs
Most common soft tissue tumors of adulthood.
Difference between conventional lipoma and angiolipoma is:
Angiolipoma has vascular structures as well as adipose
T/F: Liposarcomas are very common tumors in adults.
T/F: Liposarcoma recurrence is negligible after initial resection
False - most will recur multiple times
Benign fibrous tumor containing numerous (X) cells and treated with (Y). Sometimes difficult to distinguish from (Z) tumor.
X = spindle-shaped fibroblasts
Y = excision (Curative)
Z = fibrosarcoma
The most common soft tissue sarcoma of childhood and adolescence.
Most common neoplasm in women is (X) and (benign/malignant).
X = uterine leiomyoma
Leiomyosarcoma diagnosis is relatively straightforward due to immunohistochemical positivity of:
Ab to smooth muscle actin and desmin
Leiomyosarcoma: (painful/painless), (soft/firm) mass. Histologically composed of (X) cells.
X = spindled
T/F: Rhabdomyosarcomas tend to be very aggressive.
Most frequent primary tumor of the heart in infants and children. Often associated with (X).
X = tuberous sclerosis