03b: Bone/Soft Tissue Flashcards Preview

Oncology > 03b: Bone/Soft Tissue > Flashcards

Flashcards in 03b: Bone/Soft Tissue Deck (27):
1

(X) tumor: round to oval sessile masses projecting from the sub-periosteal surface of the bone cortex. Most commonly seen in the (Y) bones of (young/old) patients.

X = osteoma
Y = skull/facial
Middle-aged

2

Osteomas are (slow/fast)-growing tumors. Multiple osteomas are seen in (X) disease.

Slow (little consequences except for mass effect from growth);
X = Gardner Syndrome (a variant of FAP)

3

Excluding bone marrow tumors (myeloma/lymphoma), what's the most common primary malignant bone tumor?

Osteosarcoma

4

Osteosarcoma: tumor cells actively (produce/degrade) (X). Seen most commonly in (young/old) patients.

Produce;
X = bone matrix

Very young (under 20 y.o.) and elderly

5

Osteosarcoma: tumor usually arises from (epiphysis/metaphysis/diaphysis) of (short/long) bones, especially around which joint?

Metaphysis
Long
Knee

6

T/F: Osteosarcomas behave aggressively with a tendency to metastasize.

True

7

Benign tumors of hyaline cartilage.

Chondroma/enchondroma

8

Most common intraosseous cartilage tumor. Usually diagnosed in (young/old) patients.

Chondroma/enchondroma

Young (20-40)

9

Multiple enchondromas are seen in (X) Disease or in (Y) disease, if associated with hemangiomas.

X = Ollier
Y = Maffucci Syndrome

10

Enchondromas are usually (small/large) in size, (symptomatic/asymptomatic), and treated with (X).

Small (under 3 cm);
Asymptomatic
X = observation or curettage

11

List the first and second most common matrix-producing malignant bone tumors.

1. Osteosarcoma
2. Chondrosarcoma

12

Chondrosarcoma typically grows in which part of skeleton? It's clinically (symptomatic/asymptomatic).

Central skeleton;
Symptomatic (painful, enlarging mass)

13

Second most common group of bone sarcomas in kids:

Ewing sarcoma

(first is osteosarcoma)

14

Ewing sarcoma: chromosomal translocation involving (X) gene on which chromosome?

X = EWS
Chrom 22

15

Malignant soft tissue lesions in general, tend to be very (nonaggressive/aggressive) tumors. They have a propensity to metastasize to (X).

Aggressive
X = lungs

16

Most common soft tissue tumors of adulthood.

Lipomas

17

Difference between conventional lipoma and angiolipoma is:

Angiolipoma has vascular structures as well as adipose

18

T/F: Liposarcomas are very common tumors in adults.

True

19

T/F: Liposarcoma recurrence is negligible after initial resection

False - most will recur multiple times

20

Benign fibrous tumor containing numerous (X) cells and treated with (Y). Sometimes difficult to distinguish from (Z) tumor.

Nodular fasciitis
X = spindle-shaped fibroblasts
Y = excision (Curative)
Z = fibrosarcoma

21

The most common soft tissue sarcoma of childhood and adolescence.

Rhabdomyosarcoma

22

Most common neoplasm in women is (X) and (benign/malignant).

X = uterine leiomyoma
Benign

23

Leiomyosarcoma diagnosis is relatively straightforward due to immunohistochemical positivity of:

Ab to smooth muscle actin and desmin

24

Leiomyosarcoma: (painful/painless), (soft/firm) mass. Histologically composed of (X) cells.

Painless, firm
X = spindled

25

T/F: Rhabdomyosarcomas tend to be very aggressive.

True

26

Most frequent primary tumor of the heart in infants and children. Often associated with (X).

Rhabdomyoma

X = tuberous sclerosis

27

T/F: Rhabdomyomas require immediate resection/therapy due to aggressive nature.

False - often regress spontaneously