Flashcards in 12.1 - Drugs used in Psychiatric Diseases Deck (21)
What are the 3 core symptoms of depression and associated symptoms?
Core - anhedonia (lacking pleasure from things), decreased energy, low mood
Associated - Loss of conc, decreased apetite, sleep disturbance, irritability
What are the 2 theories behind the development of depression?
1) Monoamine neurotransmittters are deficient
2) Monoamine receptors are deficient
What are the 4 classes of antidepressants?
Selective serotonin reuptake inhibitors (SSRIs), TCAs, Serotonin-noradrnaline reuptake inhibitors (SNRIs), Monoamine oxidase inhibitors
Why are MAOIs rarely used?
Serious ADRs and DDIs
give 2 examples SSRI drugs
Give SSRI ADRs
Serotonin syndrome, Stimulate CNS, reproductive dysfunction in males, Insomnia
Give the MoA of TCAs
Block reuptake of serotonin and noradrenaline at presynaptic membrane
Give 2 examples of TCAs
Give ADRs of TCAs
Thrombocytopenia, Cardiac (arrhythmia, MI, Stroke), Anticholinergic (tachy, urinary retention etc), seizures
Give an example SNRIs
Give the positive symptoms of schizophrenia
hallucinations, disturbances of thinking, delusions, behavioural change
Give the negative symptoms of schizophrenia
Social withdrawal, apathy, anhedonia
Give the cognitive symptoms of schizophrenia
selective attention, poor memory, reduced astract thought
What is the main theory behind development of schizophrenia?
Too much dopamine being released
How do typical anti-psychotics work in schizophrenia? Name 2 examples
examples - haloperidal, chloropromazine
How do atypical anti-psychotics work in schizophrenia? Give 4 example drugs. Why are they preferred?
examples - risperidone, olanzipine, clozapine, quetiapine
preferred due to less ADRs
Give the ADRs of antipsychotics
Weight gain (esp olanzipine), hyperprolactinemia, extra-pyramidal side effects, cardiac toxicity
Fear out of proportion of the situation so that individuals undergo avoidance or physical symptoms e.g. light headedness, SOB
How do you treat anxiety disorders? What is their MoA? How would you treat an overdose? ADRs?
MoA - Act on GABARs to enhance effect
ADRs - dependence, drowsiness, dizziness
Overdose treated with flumazenil - BZD antagonist
Define bipolar disorder
episodes of mania and dperession with poor concentration, sleep, rapid speech, poor judgement