12.1 - Drugs used in Psychiatric Diseases Flashcards Preview

ESA 5 - Pharmacology > 12.1 - Drugs used in Psychiatric Diseases > Flashcards

Flashcards in 12.1 - Drugs used in Psychiatric Diseases Deck (21):
1

What are the 3 core symptoms of depression and associated symptoms?

Core - anhedonia (lacking pleasure from things), decreased energy, low mood
Associated - Loss of conc, decreased apetite, sleep disturbance, irritability

2

What are the 2 theories behind the development of depression?

1) Monoamine neurotransmittters are deficient
2) Monoamine receptors are deficient

3

What are the 4 classes of antidepressants?

Selective serotonin reuptake inhibitors (SSRIs), TCAs, Serotonin-noradrnaline reuptake inhibitors (SNRIs), Monoamine oxidase inhibitors

4

Why are MAOIs rarely used?

Serious ADRs and DDIs

5

give 2 examples SSRI drugs

Citalopram, Fluoxetine

6

Give SSRI ADRs

SSRI
Serotonin syndrome, Stimulate CNS, reproductive dysfunction in males, Insomnia

7

Give the MoA of TCAs

Block reuptake of serotonin and noradrenaline at presynaptic membrane

8

Give 2 examples of TCAs

imipramine, lofepramine

9

Give ADRs of TCAs

TCA'S
Thrombocytopenia, Cardiac (arrhythmia, MI, Stroke), Anticholinergic (tachy, urinary retention etc), seizures

10

Give an example SNRIs

Venlafaxine

11

Give the positive symptoms of schizophrenia

hallucinations, disturbances of thinking, delusions, behavioural change

12

Give the negative symptoms of schizophrenia

Social withdrawal, apathy, anhedonia

13

Give the cognitive symptoms of schizophrenia

selective attention, poor memory, reduced astract thought

14

What is the main theory behind development of schizophrenia?

Too much dopamine being released

15

How do typical anti-psychotics work in schizophrenia? Name 2 examples

D2 antagonists.
examples - haloperidal, chloropromazine

16

How do atypical anti-psychotics work in schizophrenia? Give 4 example drugs. Why are they preferred?

D2 antagonists
examples - risperidone, olanzipine, clozapine, quetiapine
preferred due to less ADRs

17

Give the ADRs of antipsychotics

Weight gain (esp olanzipine), hyperprolactinemia, extra-pyramidal side effects, cardiac toxicity

18

Define anxiety

Fear out of proportion of the situation so that individuals undergo avoidance or physical symptoms e.g. light headedness, SOB

19

How do you treat anxiety disorders? What is their MoA? How would you treat an overdose? ADRs?

Benzodiazepines
MoA - Act on GABARs to enhance effect
ADRs - dependence, drowsiness, dizziness
Overdose treated with flumazenil - BZD antagonist

20

Define bipolar disorder

episodes of mania and dperession with poor concentration, sleep, rapid speech, poor judgement

21

How do you treat bipolar disorder? ADRs?

Lithium mainly but sodium valproate and carbamazepine can be used
ADRs - memory problems, thirst polyuria, tremor, nephrotoxin