Pharmacogenomics Flashcards

1
Q

What is pharmacogenomics?

A

study of how to predict a patients response to a drug based on their genes. It relates single nucleotide polymorphysims with efficacy or toxicity

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2
Q

ziagen (Brand)

A

abacavir

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3
Q

epzicom (brand)

A

Abacavir and lamivudine (epzicom)

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4
Q

trizivir

A

abacavir + zidovudine + lamivudine

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5
Q

what is the test for abacavir? what does it test for?

A

HLA-B*5701 testing for hypersensitivity to ABC. Do not use if +

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6
Q

what are sx of abc hypersensitivity reaction?

A
fever
rash
GI sx
Generalized malaise/fatigue/ achi
SOB, cough, or pharyngitis
IF 2 or more sx STOP!
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7
Q

test for clopidogrel?

A

CYP219 genyotype. Poor metabolizers vs high metabolizers. Poor: dont make much of the active compound so they are gonna have CV events. Use another alternative

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8
Q

test for carbamezapmine?

A

HLA-B 1502 if asian ancestry. puts pts at rid for skin reactions ust as SJS and toxic epidermal necrolysis

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9
Q

carbamazepine brand

A

tegretol

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10
Q

traztuzumab

A

Herceptin (brandt)

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11
Q

herceptin (brand)

A

trastuzumab

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12
Q

test for trastuzumab?

A

test for HER2 /neu oncogene. 2+ or 3+ required

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13
Q

which antiHIV med requires tropism testing

A

Maraviroc or Selzentry

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14
Q

which test is done for rituximab?

A

CD-20 receptor status: because malignant cells express this so its needed for efficacy of medicaitons

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15
Q

pharmacogenomic implications of pheytoin?

A

test for HLAB1502 if asian ancestry. Increases riks fo SJS and TEN if postive . AVOID

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16
Q

pharmacogenomic implications of allopurinola?

A

inc risk of SJS after a skin rash. Could lead to exfoliative, urticarial and purpuric lesions. HLA B5801 allele. D/c at first sight of a rash

17
Q

pharmacogenomic implications of codeine?

A

extensive CYP2D6 metabolizers increase risk of being affected by converting more codeine to morphine

18
Q

pharmacogenomic implications of warfarin?

A

cyp2c9 genotypes certain ones would require more INR monitoring

19
Q

which isomer of warfarin is stronger and which one and is metabolized by CYp 2c(

A

S isomer