3. Inflammatory bowel disease Flashcards Preview

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Flashcards in 3. Inflammatory bowel disease Deck (10)
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1

name 4 ulcerative colitis symptoms

- bloody diarrhoea,
- (mild) abdominal pain during diarrhoeal attacks
- tenesmus
- malaise/fever

2

name 3 crohn's disease symptoms

- non-bloody diarrhoea,
- severe abdominal pain
- malaise/fever/anorexia

3

name 3 crohn's disease signs

- weight loss and malnutrition
- abdominal mass (relatively common)
- anal and perianal lesions

4

is UC and CD inflammation acute or chronic

UC = recurrent acute inflammation with intervening quiescent phases

CD = chronic relapsing inflammation

5

which parts of the GI tract are affected by UC and CD

UC = only colon (always with rectal involvement) but not anus

CD = any part of GI system inc. anus but not rectum

6

is inflammation of affected region continuous/discontinuous in UC and CD

UC = continuous

CD = skip lesions

7

is inflammation in UC and CD superficial or deep

UC = superficial, limited to mucosa and submucosa

CD = deep - transmural, inc. serosa

8

what are the microscopic differences between UC and CD

UC
- widespread irregular superficial ulceration (sloughing off of mucosal layer)
- abnormal crypt architecture
- no granulomas
- normal wall thickness, minimal fibrosis

CD
- fissured ulceration causing 'cobblestone' appearance
- normal crypt architecture
- granulomas
- wall thickened, marked wall fibrosis

9

should colectomy be performed in UC or CD and why

in UC due to significantly increased risk of colon cancer

10

name 3 possible complications of CD

1- strictures - obstruction
2- fistulae, eg bowel to bowel, bowel to bladder or vagina
3- iron, folate and vit B12 deficiency... anaemia