Complement--Regal Flashcards

1
Q

Which complement activation pathway requires antibodies present?

A

classical

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2
Q

What is the order of activation for complement components?

A

142356789

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3
Q

Which two components of the complement system can themselves bind pathogen membrane via thioester bonds?

A

C3b and C4b

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4
Q

How many different forms of C3 convertase are there?

A

2

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5
Q

What is the C3 convertase in the classical pathway?

A

C4b2a

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6
Q

What is the C3 convertase in the MBL pathway?

A

C4b2a

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7
Q

What is the C3 convertase in the alternative pathway?

A

C3bBb

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8
Q

What is the C5 convertase in the alternative pathway?

A

C3bBb3b

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9
Q

What is the C5 convertase in the classical pathway?

A

C4b2a3b

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10
Q

What is the C5 convertase in the MBL pathway?

A

C4b2a3b

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11
Q

Properdin does what?

A

stabilizes C3bBb C3 convertase

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12
Q

What is the function of MASP-1 and MASP-2?

A

function with MBL to activate C4 and C2

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13
Q

Which Ig is most effective at activating complement?

A

IgM–it is found in a pentemeric form, complement requires two adjacent Fc receptors to bind to opsonized organisms

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14
Q

What does the alternative pathway recognize?

A

surface structures–LPS, flaggela, etc.

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15
Q

What are the functions of Factor B and Factor D?

A

Factor B binds C3(H20) and Factor D cleaves C3(H20)B to C3bBb

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16
Q

What is the function of S-protein?

A

deactivates the C5b-9 pore-forming complex in the serum

17
Q

High sialic acid = good/poor binding

A

poor (we have high)

18
Q

Factor H function

A

C3 convertase fluid phase inhibitor

19
Q

C1 inhibitor deficiency

A

hereditary angioedema

–complement activation like crazy

20
Q

DAF (CD55) and CD59 deficiency

A

paroxysmal nocturnal hemoglobinuria

21
Q

Anaphylotoxins

A

C3a and C5a

22
Q

Which receptor is the in for EBV?

A

CR2 (CD21)

23
Q

CR1 (complement receptor 1) binds what?

A

C3b and C4b (the ones on the membranes)