Benign Leukocytoses--Krafts Flashcards
50% of neutrophils in systemic circulation are…
marginated
Causes of mature neutrophilia
infection
inflammation
physiologic stress
Cytoplasmic vacuolization is seen in…
neutrophilia responding to severe infection
Promyelocytes appear in systemic circulation…
in severe infection, neutrophil precursors just differentiate and not reproduce –> granules remain because not spread out
There two terrible things can cause immature neutrophilia
severe anemia
something filling up the marrow (uh-oh)
Döhle bodies
remnants of RER in neutrophilia
Leukoerythroblastic reaction
seen in immature neutrophilia, high neutrophils and nucleated RBC
Leukoerythroblastic reaction is common in this situation
severe anemia
If you don’t have severe anemia but you have leukoerythroblastic reaction, you’re thinking
what’s in the marrow??
High lymphocyte counts as normal are seen in…
younger people
Normal immunophenotype of blood (lymphocytes)
80% T-cells
15% B-cells
5% NK-cells
Mature lymphocytosis big cause
bordetella pertussis
Reactive lymphocytosis big cause
infectious mono (Downey cells)
pediatric viral infections
immune disorders
If you see this on a CBC, you’re going to diagnose chronic myeloid leukemia
basophilia. always.
Leukocyte alkaline phosphatase activity is _________ in chronic myeloid leukemia
decreased
these cells do whatever they damn well please, which isn’t making what they should
