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Infection > Sepsis & septic shock > Flashcards

Sepsis & septic shock Flashcards

1
Q

What is the definition of sepsis?

A

Systemic illness caused by microbial invasion of normally sterile parts of the body

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2
Q

What is the progression observed in sepsis?

A

SIRS
Sepsis
Severe sepsis
Septic shock

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3
Q

What does SIRS stand for?

A

Systemic Inflammatory response syndrome

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4
Q

What is the main factor which cause organ dysfunction in sepsis?

A

Immune reaction of the body against the infection leads to reaction

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5
Q

What is septic shock?

A

A clinical construct of sepsis with persisting hypotension which requires vasopressors in order to maintain MAP

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6
Q

What is qSOFA defined by?

A

Hypotension (systolic <100mmHg)
Altered mental state
Tachycardia
RR > 22/min

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7
Q

What is qSOFA?

A

Prognostic factor of sepsis, if >2, increased risk of poor outcome

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8
Q

For each hour’s delay in administering ABIs in septic shock, mortality increases by…

A

7.6%

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9
Q

What is the main intervention for sepsis?

A

SEPSIS 6

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10
Q

What is the pathology behind sepsis?

A

Originates from a breach of host barrier (Physical or immunological)
Organisms enter blood resulting in septic state

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11
Q

What are the 3 phases of pathogenesis in sepsis?

A

Release of bacterial toxins
Release of mediators
Effects of specific excessive mediators

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12
Q

What are some examples of toxins released by gram +ve bacteria?

A

Superantigens

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13
Q

What type of mediators can be released in response to infection?

A

Endotoxin

Exotoxin

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14
Q

What type of endotoxins are released?

A

LPS

LTA

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15
Q

What type of exotoxins are released?

A

Superantigens

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16
Q

What 2 types of mediators are released in response to sepsis?

A

Th1

Th2

17
Q

What balance is lost in sepsis?

A

Pro-inflammatory

Compensatory anti-inflammtory

18
Q

An increase in ______ response results in multi organ failure & death

A

Pro-inflammatory

19
Q

An increase in _____ can lead to immunoparalysis & uncontrolled infection

A

Compensatory anti-inflammatory

20
Q

What are some of the general features of sepsis?

A 
Fever >38C
Hypothermia <36C
Tachycardia
Tachypnoea
Altered mental state
Hyperglycaemia

Infection (7 decks)

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