Motor Neurone Disease Flashcards
MND is untreatable. TRUE/FALSE?
TRUE
the treatments we have are not effective at improving progosis
Do patients with MND have Upper motor neuron symptoms, lower motor neuron symptoms or sensory symptoms?
Can have both UMN and LMN symptoms
NO SENSORY SYMP
What si the most common subtype of MND?
Amyotrophic lateral sclerosis
What is the median prognosis of MND after prognosis?
3 years
MND is becoming more common. TRUE/FALSE?
TRUE
mechanism unknown
Is MND slightly more common in males or females?
Males
Are most cases of MND sporadic or familial?
90% sporadic
10% Familial
The diagnosis of sporadic MND peaks at what ages?
50-75
if not diagnosed by 80, likelihood goes down
ALS is less common in non-Caucasian populations. TRUE/FALSE?
TRUE
=> more common in caucasians
How is MND usually classified?
UMN - Primary lateral sclerosis
LMN - Primary Muscular Atrophy
Mix of the two = ALS
If patients with ALS exhibit signs of upper and lower motor neuron dysfunction, what symptoms can they have?
Brisk reflexes (UMN) Muscle wasting
If MND has a bulbar onset, what activities are affected?
Speech
Swallowing
What is the prognosis of ALS compared to other types of MND?
ALS - poor prognosis (3-5 years)
Primary Lateral Sclerosis (>5yrs)
Progressive Muscular atrophy (variable)
What gene should you test for in ALS with frontotemporal dementia (FTD-MND)
C9 ORF 72
Give examples of UMN signs seen in MND?
Increased tone Hyper-reflexia Extensor plantar responses Spastic gait Slow movement
