9. Cardiovascular System Drugs Flashcards Preview

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Flashcards in 9. Cardiovascular System Drugs Deck (8)
1

Class 1/ sodium channel blockers are used to prevent which condition?

After depolarisations as sodium channels in the open and inactivated state are blocked

2

Give an example of a class 1 drug

Lidocaine

3

What do class 2 drugs do and how do they work?

Beta blockers (block beta 1 adrenoreceptors)
Decreases slope of pacemaker potential in SAN
Inhibits adenyl cyclase so negative inotropy

4

What are class 3 drugs and why are they not used?

They prolong the action potential by blocking K+ channels
(In theory stop after depolarisations by increasing absolute refractory period)
Actually can be pro-arrhythmic so not used

5

How do ACE inhibitors work?

Prevent formation of angiotensin II therefore causing dilation of arterioles and veins - decreases preload and after load

Angiotensin II also promotes aldosterone release - ACE inhibitors therefore reduce water retention hence decreased blood volume and preload on the heart

6

What is the primary function of organic nitrates in the treatment of angina?

Venodilation to decrease venous pressure hence decreasing preload on the heart

7

What is the secondary function of organic nitrates in the treatment of angina?

Acts on coronary arteries improving O2 delivery

8

The atria being stretched can lead to what condition?

Atrial fibrillation due to re entry loops being generated due to damaged myocardium