Aliskiren Flashcards by Daniel Aastrup

Q

Aliskiren

Virkningsmekanisme

A

Specifik hæmmer af renins katalytiske virkning. Blokerer renins active site, hindrer herved reaktionen angiotensinogen –> angiotensin I.

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Q

Aliskiren

Indgift

A

Peroral indgift

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Q

Aliskiren

Indikationer

A

Anvendes til behandling af hypertension. Kunne have relevans ved hjerteinsufficiens, men studie viste ingen forbedring men øget risiko for hyperkaliæmi, hypotension og nedsat nyrefunktion.

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Q

Aliskiren

Kontraindikationer

A

Behandling med ACE-hæmmere eller angiotensin-II-receptor-antagonister ved ptt. med diabetes og/eller nedsat nyrefunktion.

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