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Hematology Oncology > Blood Transfusion > Flashcards

Flashcards in Blood Transfusion Deck (30):
1

Type AB individuals are?

Universal recipients

2

Type O individuals are?

Universal dOnors

3

Absence of D antigen means?

Rh negative

4

Type A produce what antibodies?

B antibodies

5

Type B produce what antibodies?

A antibodies

6

What fluid is use for blood product transfusion?

Normal saline ONLY

7

What is the clinical response for packed red blood cells (PRBC)?

Increased hemoglobin 1g/dL and hematocrit by 3%

8

What does fresh frozen plasma contain?

Coagulation factors and plasma proteins, good for correcting coagulopathies.

9

What does cryoprecipitate do?

Provides a source of fibrinogen, factor VIII, and von Willibrand factor.

10

Pts with high titer antibodies to specific agents or antigens provide what?

Hyperimmune globulins
- Anti-D (RhoGAM, WinRho)
- Antisera (HBV, smallpox)

11

What is the MCC of acute hemolytic rxn?

Human error- ABO incompatibility

12

What is the most dangerous acute transfusion reaction?

Acute hemolytic rxn

13

What are some clinical manifestations of acute hemolytic rxn?

Fever/chills

HA

N/V

LBP

Tachy/HypoTN

14

What is the management of acute hemolytic rxn?

STOP transfusion

Check ppw for clerical errors

Send donor bag back to blood bank for culture.

15

What is the MC sxs of febrile non-hemolytic rxn?

Fever and chills occurring soon after initiation of transfusion

16

What is the management of febrile non-hemolytic rxn?

STOP transfusion

17

S/sx of allergic rx/anaphylaxis?

Pruritus/Urticaria (MC-mild sxs)

Bronchospasm, anaphylaxis, hypoTN (severe sxs)

18

What is the management of allergic rx/anaphylaxis?

STOP transfusion and give antihistamine

Give epi if severe

19

What is the pathology of transfusion-related acute lung injury?

Non-cardiogenic pulmonary edema

20

What is the management of transfusion-related acute lung injury?

STOP transfusion

O2

21

How do you prevent hypervolemia?

Slow transfusion, transfuse 1 unit over 4 hrs and coadminister of diuretic

22

S/sx of sepsis from bacterial contamination of stored blood?

High fevers, rigors, and manifestations of shock

23

What is the management of sepsis?

STOP transfusion

Broad spec antibiotics (gram + and - coverage)

24

What is the MC complications following massive transfusions?

Bleeding - related to platelet and coag factor deficiencies

25

What is transfusion related graft vs host disease?

Donor lymphocytes recognize the immunocompromised recipient as foreign and targeted for destruction
- occurs 4-10 days post-transfusion

26

What is the ratio risk of HIV 1/2 disease transmission?

1 in every 2,300,000

27

What is the ratio risk of Hep B disease transmission?

1 in every 220,000

28

What is the ratio risk of Hep C disease transmission?

1 in every 1,800,000

29

What are the 2 diagnostic test for acute hemolytic rxn?

Hemoglobinuria

Hemoglobinemia

30

Indication for whole blood use?

Acute hemorrhage >25%