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Flashcards in Coagulopathies Deck (29):
1

Thrombotic Thrombocytopenic Purpura (TTP) hereditary deficiency?

ADAMTS 13 Deficiency

2

What is the Thrombotic Thrombocytopenic Purpura (TTP) pentad?

- Fever

- Thrombocytopenia

- Renal Failure

- Neurologic findings

- Anemia

3

What is the tx for Thrombotic Thrombocytopenic Purpura (TTP)?

Plasmapheresis

4

Thrombocytopenia diagnostic test?

Examination of peripheral smear

5

Thrombocytopenia treatment?

- Treat underlying cause

- Platelet transfusion (ultimate tx)

6

What is the pathophysiology of Idiopathic Thrombocytopenic Purpura (ITP)?

Autoimmune antibody formation against host platelets

7

With Idiopathic Thrombocytopenic Purpura (ITP) the reticuloendothelial system binds to what?

Self-immunoglobulins attached to the platelets

8

Acute Idiopathic Thrombocytopenic Purpura (ITP) seen in who and precedes what?

Children and viral infection

9

Platelet and CBC findings for Acute Idiopathic Thrombocytopenic Purpura (ITP)?

- Platelet count is low

- CBC is normal

- No schistocytes

10

Tx for Idiopathic Thrombocytopenic Purpura (ITP)?

- Adrenal corticosteroids #1

- IV immunoglobulin #2

11

What occurs with platelets with Heparin-Induced Thrombocytopenia?

Drop-in platelets a few days after heparin administration, will lead to clots

12

Acute Hemolytic Uremic Syndrome (HUS) is characterized by?

- Hemolytic anemia

- Thrombocytopenia

- Severe renal failure

13

Hemolytic Uremic Syndrome (HUS) is the MCC of?

Acute renal failure in children (<5 yrs of age)

14

What is the leading cause of Hemolytic Uremic Syndrome (HUS)?

E. Coli

15

What are some general characteristics of Disseminated intravascular coagulation (DIC)?

Bleeding and thrombosis occurring simultaneously.

- Consumption of platelets, fibrin, and coag factors

- Fibrinolytic mechanisms are activated resulting in hemorrhage

16

Disseminated intravascular coagulation (DIC) is MC in what patients?

Critically ill, ICU pts.

17

MCC of Disseminated intravascular coagulation (DIC)?

Gram-negative sepsis (ie. elderly with UTI infection)

18

What is a complication with Disseminated intravascular coagulation (DIC)?

Amniotic fluid emboli

19

Rattlesnake venom can causes what?

Disseminated intravascular coagulation (DIC)

20

What lab test as decreased with Disseminated intravascular coagulation (DIC)?

Fibrinogen level and platelet count

21

Tx for Disseminated intravascular coagulation (DIC)?

- Cryoprecepitate- replaces clotting factors and fibrinogen

- FFP- replaces all clotting factors

22

What is a cause of inherited hypercoagulable state?

Antiphospholipid antibody syndrome (APAS)

23

What is the presentation of antiphospholipid antibody syndrome (APAS)?

- Arterial or venous thrombosis (DVT in arms)

- Recurrent fetal loss (multiple miscarriages)

24

What is Von Willebrand Disease (vWD)

- MC inherited bleeding disorder (autosomal dominant disorder)

- Factor XIII defect

25

Treatment for type 1 Von Willebrand Disease (vWD)?

Desmopressin (DDAVP)

26

Treatment for type 3 Von Willebrand Disease (vWD)?

Factor VIII concentrates

27

What is not recommended for tx for Von Willebrand Disease (vWD) and why?

- Cryoprecipitate (risk of viral transmission)

28

What is the MC inherited hypercoagulability disorder among Caucasians?

Factor V Leiden

29

Clinical finding of Factor V Leiden?

Thromboembolism (DVT and PE are MC)