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Flashcards in Box 3 Deck (71)
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1

Trade name for Esmolol?

Brevibloc

2

Esmolol classification?

Cardioselective Beta Blocker/B-1 adrengeric receptor antagonist

Class II anti-arrhythmic agent.

3

Esmolol MOA?

By blocking adrengeric activity of epi and norepi, it decreases inotropic contractility, heart rate, and conduction.

Esmolol increases atrioventricular refractory time decreases oxygen demand of the myocardium, and decreases atrioventricular conduction.

A minor Beta 2 blockade has been reported with high IV infusion doses

4

Esmolol MOA?

By blocking adrengeric activity of epi and norepi, it decreases inotropic contractility, heart rate, and conduction.

Esmolol increases atrioventricular refractory time decreases oxygen demand of the myocardium, and decreases atrioventricular conduction.

A minor Beta 2 blockade has been reported with high IV infusion doses

5

Indications for Esmolol use?

Supraventricular Tachycardia (SVT); perioperative hypertension

6

Loading dose of Esmolol (flood)

Loading dose: 50-300 mg/kg/min

7

Onset, peak and duration of Esmolol?

Rapid onset and short duration.

Onset: 1-2 minutes.
Peak effect: 5-6 minutes.
Duration: 10-20 minutes.

Do not infuse for more than 48 hours.

8

What all routes can you infuse Esmolol?

ONLY IV

9

Can Esmolol cause hypoglycemia? Does Esmolol cross the BBB and the placenta?

Yes, yes, yes

10

elimination half time of Esmolol?

about 9 minutes

11

How is Esmolol cleared from the plasma and tissues?

ester hydrolysis

12

Classification of Labetalol?

combined alpha and Beta- adrenergic Receptor Antagonist.

13

Contraindications of Labetalol?

bronchial asthma, 2nd-3rd degree heart block, hepatic failure.

14

IV dose of labetalol?

0.1-0.5mg/kg
(start with 5-10mg)

15

Labetalol MOA?

exhibits selective α1 and non-selective β1- and β2-adrenergic antagonist effects. Presynaptic α2 receptors are spared by labetalol such that released norepinephrine can continue to inhibit further release of catecholamines via the negative feedback mechanism resulting from stimulation of α2 receptors. α to β blocking potency ratio is 1:7 IV, 1:3 Oral

16

Labetalol IV onset, peak, duration?

Onset: 1-3 min.
Peak: 5-15 min.
Duration: 20 min. - 2 hours.

17

Labetalol and inhaled anesthetics?

anesthetic inhalants may increase hypotensive effects.

18

Labetalol typically comes in a supply of what concentration?

20mg/4mL

19

Classification of Metoprolol?

Beta blocker, Beta 1 selective

20

Contraindications to Metoprolol use?

COPD, CAD, Vulnerable to hypoglycemia

21

IV dose of metoprolol?

1mg-15mg

22

Metoprolol MOA?

Selective B1-Adrenergic receptor antagonist

23

Which type of metoprolol lasts longer (has a longer elimination half-time) succinate or tartrate?

succinate 1/2 time = 5-7 hours

tartrate 1/2 time = 2-4 hours

24

onset of metoprolol?

1-5 min.

25

selectivity of metoprolol based on dose?

Selectivity is dose related and large doses become non-selective antagonist B2 receptor as well as B1

26

Metoprolol comes in a supply concentration of what?

1mg/1ml (or 5mg/5ml)

27

Classification of Neostigmine?

Anticholinesterase agent.

(increases ACH by blocking cholinesterase "what breaks it down")

28

Contraindications to Neostigmine use?

Use with caution in patients with bradycardia, bronchial asthma, epilepsy, cardiac arrhythmias, peptic ulcer, peritonitis, or mechanical obstruction of the intestines or urinary tract

29

Does of Neostigmine?

60-80 mcg/kg with a max dose of 5mg

(some sources also say 40-70mcg/kg, I guess know both?)

30

Neostigmine MOA?

It inhibits AChE by forming a drug-enzyme complex that degrades in the same manner as ACh-Cholinesterase complex, thereby increasing the concentration of endogenous ACh around the cholinoreceptors