Flashcards in Extra drug box information (4-6) Deck (10)
IV Acetaminophen is called?
Non-opioid analgesic, antipyretic
antidote for Ofimev overdose?
Dose of Ofimev for adults over 50kg?
1 gm over 15 min. q 4-6 hours.
Dose of Ofirmev for an adult under 50kg?
15mg/kg 4-6 hours, not to exeed 3gm/day
max dose per day of Ofirmev for adult over 50kg?
do not exceed 4g/day
Contraindications to Ofirmev?
Hepatotoxicity in individuals with impaired liver function. Hepatotoxicity seen in chronic alcoholics.
MOA of Ofirmev?
It has a central analgesic effect that is mediated through activation of descending serotonergic pathways. It also produces inhibition of prostaglandin synthesis. Spinal cord level it antagonizes neuro transmission by N-methyl-D-asparate substance P, (NMDA) and nitric oxide pathways.
Elimination of IV Acetaminophen?
it is eliminated by hepatic elimination by conjugation to either the glucuronide which is (55%) or sulfate which is (25%) less than 10% is oxidized by CYP2E1, 3A4 and isozymes to N-acetyl-p-benzoquininone (NAPQ1) metabolite. Which is excreted by the kidney at 1-4%.