Extra drug box information (4-6) Flashcards Preview

SUM'20 Drug Boxes > Extra drug box information (4-6) > Flashcards

Flashcards in Extra drug box information (4-6) Deck (10)
Loading flashcards...
1

IV Acetaminophen is called?

Ofirmev

2

Ofirmev classification?

Non-opioid analgesic, antipyretic

3

antidote for Ofimev overdose?

acetylcysteine

4

Dose of Ofimev for adults over 50kg?

1 gm over 15 min. q 4-6 hours.

5

Dose of Ofirmev for an adult under 50kg?

15mg/kg 4-6 hours, not to exeed 3gm/day

6

max dose per day of Ofirmev for adult over 50kg?

do not exceed 4g/day

7

Contraindications to Ofirmev?

Hepatotoxicity in individuals with impaired liver function. Hepatotoxicity seen in chronic alcoholics.

8

MOA of Ofirmev?

It has a central analgesic effect that is mediated through activation of descending serotonergic pathways. It also produces inhibition of prostaglandin synthesis. Spinal cord level it antagonizes neuro transmission by N-methyl-D-asparate substance P, (NMDA) and nitric oxide pathways.

9

Elimination of IV Acetaminophen?

it is eliminated by hepatic elimination by conjugation to either the glucuronide which is (55%) or sulfate which is (25%) less than 10% is oxidized by CYP2E1, 3A4 and isozymes to N-acetyl-p-benzoquininone (NAPQ1) metabolite. Which is excreted by the kidney at 1-4%.

10

Ofirmev Onset, peak, duration?

onset: 2.5min
peak: 2 hours
duration: 2-6 hours