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Flashcards in Brain Barriers Deck (8)
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1
Q

What three components make up the Blood Brain Barrier?

A
  1. Capillary endothelial tight junctions (primary)
  2. Pinocytic Activity in endothelial cells
  3. Astrocytic foot processes
2
Q

Which glucose configuration can travel across the BBB? Through what mechanism?

A

D-Glucose through Carrier Mediated Transport.

BBB is impermeable to L-Glucose.

3
Q

The Blood-CSF Barrier is formed by _______ .

A

tight junctions of choroid cuboidal epithelium

4
Q

What are circumventricular organs?

A

Midline ventricular structures of specialized tissues with absent BBB due to fenestrated capillaries

5
Q

How many circumventricular Organs are there? What are there names?

A
  1. Organum vasculosum (lamina terminalis)
  2. Neurohypophysis
  3. Median eminence of the Hypothalamus
  4. Subfornical Organ
  5. Subcommissural Organ
  6. Pineal Gland
  7. Area Postrema
6
Q

Which is the only circumventricular organ with an intact BBB?

A

Subcommissural organ

7
Q

What is the only paired circumventricular organ? Where is it located?

A

Area Postrema on the floor of the 4th Ventricle

8
Q

What stimulates the area postrema to induce emesis?

A

Digitalis or apomorphine