Breast Disorders in Women's Health Flashcards Preview

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Flashcards in Breast Disorders in Women's Health Deck (82)
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1

Breast Disorders

Breast fibrocystic change
Breast fibroadenomas
Mastitis
Breast abscess
Intra-ductal papilloma
nipple discharge
Breast tenderness

2

Breast Disorders

Breast fibrocystic change
Breast fibroadenomas
Mastitis
Breast abscess
Intra-ductal papilloma
nipple discharge
Breast tenderness

3

Breasts Histologically Composed of

Lobules/glands
Milk ducts
Connective tissue
Fat

4

Connective Tissue Disorders

Fibrocystic changes
Fibroadenomas

5

Issues with Duct System

May become dilated
Contain papillary neoplasms
Undergo malignant transformations

6

Blood Supply to the Breasts

Internal mammary artery
Lateral thoracic artery
Thoracodorsal artery
Thoracocramial artery
Intercostal perforating arteries

7

Lymphatic System of the Breast

Superficial and deep nodal chains through head & neck
Axilla
Deep to pectoralis muscles
Caudal to diaphragm

8

Breast Cancer

Most common malignancy in women

9

Risk Factors for Breast Cancer

Age
Family history
Race
Genetics
Early menarche
Late menopause
Increased exposure to estrogen
Use of estrogen therapy
Nulligravid state
First pregnancy after 35
Fibrocystic conditions when accompanied by proliferative changes
CA in one breast
Endometrial CA

10

Breast Cancer & Age

Increases with age
Plateau in women 50-55
Most significant risk factor after gender

11

Breast Cancer & Family History

1st degree relative i
2+ relatives with breast or ovarian CA
Breast CA younger than 50
Relatives with both breast CA & ovarian CA
1+ relative with 2 cancers
Male relatives with breast cancer

12

Breast Cancer & Race

Caucasian more likely
Individuals of Ashkenazi Jewish descent

13

Breast Cancer & Genetics

BRCA1 & BRCA2

14

Breast Cancer & Early Menarche

15

Breast Cancer & Late Menopause

>50 years old

16

Breast Cancer & Increase Exposure to Estrogen

Obesity
Persisten anovulation

17

Breast Cancer & Use of Estrogen Therapy

BSO before 35 with HRT
Postmenopausal treatment with HRT

18

Other Risk Factors for Breast Cancer

Not breastfeeding
Hx of epithelial hyperplasia with atypic
Exposure to ionizing radiation or other carcinogens
Certain dietary factors: fat, ETOH

19

BRCA 1 & BRCA2 Mutations

Disrupt protein productions
Change in one of the protein blocks to make BRCA proteins
Unable to help fix damaged DNA
Results in build up of mutations
Causes cells to divide in uncontrolled way

20

Harmful BRCA1 Mutations and Increased Risk of Other Cancers in Women

Cervical
Uterine
pancreatic
Colon

21

Male BRCA1 & BRCA2 & Increased Risk of Other Cancers

Breast
Pancreatic
Testicular
Early-onset prostate

22

Male BRCA1 & BRCA2 & Increased Risk of Other Cancers

Breast
Pancreatic
Testicular
Early-onset prostate

23

Breasts Histologically Composed of

Lobules/glands
Milk ducts
Connective tissue
Fat

24

Connective Tissue Disorders

Fibrocystic changes
Fibroadenomas

25

Issues with Duct System

May become dilated
Contain papillary neoplasms
Undergo malignant transformations

26

Blood Supply to the Breasts

Internal mammary artery
Lateral thoracic artery
Thoracodorsal artery
Thoracocramial artery
Intercostal perforating arteries

27

Lymphatic System of the Breast

Superficial and deep nodal chains through head & neck
Axilla
Deep to pectoralis muscles
Caudal to diaphragm

28

Breast Cancer

Most common malignancy in women

29

Risk Factors for Breast Cancer

Age
Family history
Race
Genetics
Early menarche
Late menopause
Increased exposure to estrogen
Use of estrogen therapy
Nulligravid state
First pregnancy after 35
Fibrocystic conditions when accompanied by proliferative changes
CA in one breast
Endometrial CA

30

Breast Cancer & Age

Increases with age
Plateau in women 50-55
Most significant risk factor after gender