C diff

Question 1

Characteristics of BI/NAP1/027

Answer 1

high level fluoroquinolone resistance
efficient sporulation
high toxin production
death 3 x normal
more likely to fail treatment with metro

Question 2

WCC in C diff

Answer 2

up

Question 3

ELISA detects

DNA based tests ID

Answer 3

toxins
toxin genes

PCR for toxin is most sens and spec

Question 4

hypervirulent strain mech

Answer 4

deleted tcdC gene which normally represses toxins A and B production

Question 5

wash hands with

Answer 5

soap and water- spores

Question 6

second relapse

Answer 6

fidaxomicin (does not work in NAP1 strains)

or

tapered and pulsed vanc

Question 7

treatment

Answer 7

mild to mod- metro
severe- oral vanc

if very severe add IV metro to oral vanc