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Flashcards in Clinical Pharmacology Deck (8)
0

Which condition can cause severe toxicities for patients receiving 5-FU?

Dihydropyrimidine dehydrogenase (DPD) deficiency. This is the first of 3 enzymes in the fluoropyrimidine metabolic pathway.

1

Which polymorphism is associated with increased toxicities (neutropenia, and probably diarrhea) due to irinotecan?

UGT1A1*28

2

Vinorelbine is extensively metabolized in the liver via which enzyme?

CYP3A

3

Compared to once-every-3-week regimen, weekly paclitaxel for metastatic breast cancer has ___ RR and time to progression.

Better

4

Patient with a history of Gilbert's syndrome receiving FOLFIRINOX developed febrile neutropenia after 1 cycle. What changes should be made for subsequent cycles?

Dose-reduce irinotecan

5

What is a pharmacodynamic endpoint?

The relationship between an administered dose of a drug and a change in a biologic target.

6

What drug converts methotrexate into inactive metabolites that can be eliminated from the body via nonrenal pathways?

Glucarpidase

7

A patient develops grade 2 neuropathy on paclitaxel. Switch to nab-paclitaxel?

No! Worse neuropathy with nab-paclitaxel.