Flashcards in Clinical Pharmacology Deck (8)
Which condition can cause severe toxicities for patients receiving 5-FU?
Dihydropyrimidine dehydrogenase (DPD) deficiency. This is the first of 3 enzymes in the fluoropyrimidine metabolic pathway.
Which polymorphism is associated with increased toxicities (neutropenia, and probably diarrhea) due to irinotecan?
Vinorelbine is extensively metabolized in the liver via which enzyme?
Compared to once-every-3-week regimen, weekly paclitaxel for metastatic breast cancer has ___ RR and time to progression.
Patient with a history of Gilbert's syndrome receiving FOLFIRINOX developed febrile neutropenia after 1 cycle. What changes should be made for subsequent cycles?
What is a pharmacodynamic endpoint?
The relationship between an administered dose of a drug and a change in a biologic target.
What drug converts methotrexate into inactive metabolites that can be eliminated from the body via nonrenal pathways?