Flashcards in Molecular Biology Deck (3)
How does azacitidine work?
Promotes hypomethylation of DNA, restoring normal gene differentiation and proliferation. Also exerts direct toxicity to abnormal hematopoietic cells in the bone marrow.
What is bortezomib's mechanism of action?
Inhibits proteasomes, enzyme complexes which regulate protein homeostasis within the cell. Specifically, it reversibly inhibits chymotrypsin-like activity at the 26S proteasome, leading to activation of signaling cascades, cell-cycle arrest, and apoptosis.