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Flashcards in Drugs Deck (36):
1

Doxorubicin

Anthracycline, cytotoxic antibiotic

Irreversible cardiomyopathy
High emetogenicity
Alopecia
Orange discolouration of urine
Radiation recall

2

Bleomycin

Cytotoxic antibiotic

Pulmonary fibrosis
Oxygen toxicity

Capped cumulative lifetime dose
Used in testicular germ cell cancer regimens

3

Docetaxel

Taxane

Fluid retention
Peripheral neuropathy
Hypersensitivity reaction

4

Paclitaxel

Taxane

Peripheral neuropathy
Myalgias
Nail changes
Skin rash
Pneumonitis

5

Pemetrexed

Folate antimetabolite

Skin rash
Myelosuppression

Premedicate with Vitamin B12 and folic acid
Used in mesothelioma

6

Methotrexate

Folate antimetabolite

Nephrotoxicity
Fluid retention due to excess fluid loading required to prevent precipitation in kidneys

Folinic acid rescue is used to prevent side effects

7

Gemcitabine

Antimetabolite - nucleoside analog

Pneumonitis

8

5-Fluorouracil

Anti-metabolite - pyrimidine analog

Diarrhoea
Coronary artery spasm
Hand and foot syndrome (plantar-palmar erythrodyesthesia or PPE)
Mucositis

Deficiency in DPD (dihydropyrimidine dehydrogenase) enzyme prediposes to increased toxicity

9

Capecitabine

Prodrug of 5-FU

Diarrhoea
Coronary artery spasm
PPE
Mucositis

10

Carboplatin

Platinum alkylating agent

Hypersensitivity
Myelosuppression (dose limiting)

Dosed on AUC

11

Cisplatin

Platinum alklyating agent

High emetogenicity
Nephrotoxicity
Ototoxicity
Peripheral neuropathy
Electrolyte wasting (K, Mg)

12

Oxaliplatin

Platinum

Cold dysasthsia - sensitivity and spasm to cold exposure
Hypersensitivity reaction
Anaphylaxis

13

Irinotecan

Topoisomerase 1 inhibitor

Bowel spasm
Cholinergic reaction - diarrhoea, flushing, abdo cramps, hypersalivation, sweating

Can pre-medicate with atropine

14

Etoposide

Topoisomerase 2 inhibitor

15

Cyclophosphamide

Alkylating agent

Haemorrhagic cystitis
AML
Bladder cancer
Infertility
Fanconi syndrome

16

Dacarbazine

Alkylating agent

High emetogenicity

17

Temozolmide

Alkylating agent

Cerebral oedema

18

Tamoxifen

Selective estrogen receptor modulator (SERM)

Hot flushes
Increased risk of endometrial cancer
Increased VTE risk
Glaucoma

19

Anastrozole/Letrozole/Exemestane

Aromatase inhibitors (non steroidal and steroidal)

Arthralgia
Osteoporosis
Hot flushes
Vaginal dryness

20

Bicalutamide/Flutamide

Androgen receptor antagonist

Gynaecomastia
Breast pain
Hot flushes
Reduced libido

21

Goserelin/Leuprorelin

GnRH agonist

Initial tumour flare - bone pain
Reduced bone mineral density
Hot flushes
Decreased libido

22

Abiraterone

Androgen synthesis inhibitor

Hypertension
Hypokalaemia
Fluid retention

ADRs due to mineralocorticoid excess which is reduced by giving concomitant steroids

23

Imatanib

Tyrosine kinase inhibitor
Used in GIST and CML

Fluid retention

24

Lapatanib

Dual tyrosine kinase inhibitor (HER2 and EGFR)
Used in metastatic HER2 positive breast ca

Diarrhoea
Interstitial lung disease

25

Sunitinib/Pazopanib

Multi-targeted tyrosine kinase inhibitor
Used in metastatic clear cell renal cancer

Hypertension
Bleeding
Impaired wound healing
Thromboembolism
Yellow skin discolouration
PPE

26

Erlotinib/Gefitinib

EGFR tyrosine kinase inhibitor
Used in EGFR mutant lung cancer

Acneiform rash
Diarrhoea
Pneumonitis

27

Crizotinib

ALK tyrosine kinase inhibitor
Used in ALK mutant lung cancer

Sinus bradycardia
Visual disturbance
Pneumonitis
Diarrhoea

28

Dabrafenib/Trametinib

Dabrafenib - BRAF inhibitor
Trametinib - MEK inhibitor
Used in BRAF mutant melanoma

Non infectious fevers
Skin SCCs and hyperkeratosis
Ocular toxicity

29

Trastuzumab

Monoclonal antibody against HER2
Used in HER2 positive breast ca

Reversible cardiomyopathy
Flu like symptoms
Hypersensitivity reactions

30

Pertuzumab

Monoclonal antibody preventing dimerization of HER2
Used in metastatic HER2 positive breast ca

Reversible cardiomyopathy
Hypersensitivity reaction

31

Cetuximab/Panitunumab

Monoclonal antibody against EGFR
Used in KRAS wildtype metastatic colorectal cancer

Hypersensitivity
Rash

32

Trastuzumab + emtansine (TDM1)

Monoclonal antibody against HER2 linked to a microtubule inhibitor
Used in metastatic HER2 positive breast cancer (2nd line)

Reversible cardiomyopathy
Thrombocytopenia

33

Rituximab

Monoclonal antibody against CD20
Used in non Hodgkins lymphoma

Flu like symptoms
Hypersensitivity
Rarely associated with PML (progressive multifocal leukoencephalopathy)

34

Bevacizumab

Monoclonal antibody against VEGF

Haemorrhage
Thromboembolism
Wound healing
Hypertension
Proteinuria

35

Ipilimumab

Monoclonal antibody against CTLA-4
Used in metastatic melanoma

Immune side effects:
Colitis
Endocrinopathy - hypophysitis, adrenal insufficiency
Rash, TEN
Hepatotoxicity
Neuro - GBS, myasthenia

36

Pembrolizumab/Nivolumab

Monoclonal antibody against PD1
Used in metastatic melanoma

Immune side effects:
Pneumonitis
Colitis
Nephritis
Endocrinopathy
Hepatitis