G-protein linked 2nd messangers Flashcards Preview

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Flashcards in G-protein linked 2nd messangers Deck (12)
1

Gq 2nd receptor

  • inc Phospholipase C
    • PIP2
      • DAG--> PKC
      • IP3-->Inc Ca2+

H alpha V 1

M1 and M3

2

Gs

  • Adenylate cyclase
    • ATP-->cAMP
      • PKA
        • increase Ca (heart)
        • Myosin light chain kinase (sm muscle)

 

B1, D1,

B2, H2, V2

3

Gi

  • Adenylate cyclase
    • ATP-->cAMP
      • PKA
        • increase Ca (heart)
        • Myosin light chain kinase (sm muscle)

M2, A2, D2

4

Define function of (cholinergic)

Hemicholinium

blocks up take of choline

5

Define function of (cholinergic)

Vesamicol

blocks ACh going into vesicles

6

Define function of (cholinergic)

Botulinum 

blocks release of ACh

7

Define function of (noradrenergic)

Metryosine

blocks conversione of Tyrosine to DOPA

8

Define function of (noradrenergic)

Reserpine

Blocks Dopamine going into vesicles

9

Define function of (noradrenergic)

Bretylium

Guanethidine (not used clincially)

Blocks release of dopamine

10

Define function of (noradrenergic)

Amphetamine

increases release of Dopamine from noradrenergic neuron.

11

Define function of (noradrenergic)

Cocain, TCAs, amphetamine

Blocks reuptake of dopamine in neuron terminal.

12

Define function of (noradrenergic)

  • alpha 2
  • ATII

  • Alpha 2:  blocks release of dopamine
  • ATII: stimulates the release of dopamine