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Flashcards in Sympathomimetics Deck (28)
1

Applications

  • anaphylaxis
  • open angle galucoma
  • asthma, hypotension,
  • alpha effects predominat at high doses

define drug & effect

  • Epinephrine
  • Beta>alpha

2

Applications

Hypotension (but dec renal perfusion)

define drug & effect

  • Norepinehrine
  • alpha 1> alpha 2> beta 1

3

Applications

  • Electrophysiologic evaluation of tachyarrhythmias
  • Can worsen ischemia

define drug & effect

  • Isoproterenol
  • Beta 1 = beta 2

4

Applications

Unstable bradycardia, heart failure, shock; inotropic and chronotropic alpha effects predominate at high doses

define drug & effect

  • Dopamine
  • D1=D2> beta> alpha

5

Applications

  • Heart failure (inotropic>chronotropic)
  • cardiac stress testing

define drug & effect

  • Dobutamine
  • Beta 1 > beta 2, alpha

6

Applications

  • Hypotension (vasoconstrictor)
  • Ocular procedures (mydriatic)
  • Rhinitis (decongestant)

define drug & effect

  • Phenylephrine
  • alpha 1> alpha 2

7

Applications

  •                 for acute asthma
  •               for long term asthma or COPD controle
  •            to reduce premature tureine contracitons.

define drug & effect

Applications

  • Albuterol for acute asthma
  • Salmeterold for long term asthma or COPD control
  • Terbutaline to reduce premature uterine contractions.

Beta2 > Beta1

8

Applications

  • Narcolepsy, obesity, attention defficit disorder
  • indirect general agonist, reuptake inhibitor also relseaers stored catecholamines

define drug

Amphetamine

9

Applications

  • Nasal decongestion, urinary incontinece, hypotension
  • Indirect general agonist, releases stored catecholamines

define drug

Ephedrine

10

Applications

Causes vasoconstriction and local anesthesia

NEVER give Beta blockers if               intoxication is supseected (can lead to unopposed alpha1 activation and extreme hypertension).

indirect genealt agonsits, reuptake inhibitor

define drug & effect

cocaine!

11

Applications

  • Hypertenisive urgency (limited situations) does not decrease renal blood flow
  • ADHD, sever pain, and vairety of off-label inidcaitons (ethanol and opioid w/drawal)

toxicity

  • CNS depression, bradycardia, hypotension, respiratory depression and small pupil size

ID drug

Clonidine

12

Applications

  • Hypertension in pregnancy
  • safe in pregnancy

toxicity

  • Direct coombs + hemolytic anemai, SLE-like syndrome

ID drug

Alpha-methyldopa

13

Applications

Pheochromocytoma (used preoperatively) to prevent catecholamine (hypertensive) crisis

Phenoxybenzamine

(irreversible)

14

Phenoxybenzamine

SE

  • Othrostatic hypertension
  • Reflex tachycardia

15

Applications

Give to pts on MAO inhibitors who eat tyramine containing foods

Phentolamine

(reversible)

16

Applications

  • Urinary symptomes of BPH
  • PTSD                
  • Hypertenstion (except for              )

  • Alpha-1 selective (-osin ending)
  • Prazosin, terazosin, doxazosin, tamsulosin
  • PTSD:  Prazosin
  • Hypertension (except tamsulosin)

17

Alpha-1 selective (-osin ending) 

SE

1st dose orthostatic hypertension, dizziness, headache

18

Applications

Depression

(alpha-2)

  • What is the drug
  • SE of the drug

  • Mirtazapine
  • Sedation, inc serum cholesterol, inc appetite

19

What are the effects of beta-blockers on:

Angina pectoris

  • dec heart rate and contractility
  • resulting in O2 consumption

20

What are the effects of beta-blockers on:

MI

which 3 drugs cause this effect (BC-M)

  • dec mortality
  • Bisoprolol, carvedilol, metoprolol

21

What are the effects of beta-blockers on:

SVT (metoprolol, esmolol)

  • dec AV conduction velocity
  • (class II antiarrhynthmic)

22

What are the effects of beta-blockers on:

Hypertension

dec what 2 things and def the mech of actino on kidneys)

  • dec Cardiac output
  • dec renin secretion (due to B1-receptor blockade on JGA cells)

23

What are the effects of beta-blockers on:

CHF

slows progression of chronic failure

24

What are the effects of beta-blockers on:

Glaucoma (timolol)

dec secretion of aqueous humor

25

What drug has the following toxicity:

  • Impotence
  • Cardiovascular adverse effects (bradycardia, AV block, CHF) 
  • CNS adverse effects (seizures,sedation, sleep alterations)
  • dyslipidemia (metoprolol)
  • asthematics/COPDers (may cause exacerbation)

 

beta-blockers

26

What class of drugs do you avoid in cocaine users

and why?

  • beta-blockers
  • to avoid risk of unopposed alpha-adrenergic receptor agonist activity

27

which class of beta blockers go from

  • A-M
  • N-Z
  • have modified suffixes (-olol)

  • B1-Selective antagonists 
  • B1=B2 nonselective antagonists
  • carvedilol, labetalol

28

Which drug 

combineds cardiac selective beta-1 adrenergic blockade with stimulation of beta3 receptors,

which activate what?

  • Nebivolol
  • activates nitric oxide synthase in the vasculature