Guillain Barre Syndrome Flashcards Preview

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Flashcards in Guillain Barre Syndrome Deck (14):
1

 

 

What is Guillain-Barre syndrome?

 

Acute demyelinating polyneuropathy

An acute inflammatory response which most-often occurs several weeks after viral infection, usually GI/GU.

 

2

 

 

How long after infection does paralysis occur in someone with Guillain-Barre syndrome?

 

 

1-3 weeks

3

 

 

What are causes of Guillain-Barre Syndrome?

 

  • Campylobacter jejuni
  • CMV
  • Mycoplasma
  • Herpes Zoster
  • HIV
  • EBV
  • Vaccination

4

 

 

Why does Guillain-Barre Syndrome occur?

 

 

Molecular mimicry, i.e. sharing of homologous epitopes between microorganism liposaccharides and nerve gangliosides (e.g. GM1), is the possible mechanism.

5

 

 

What are symptoms/signs of Guillain-Barre syndrome?

LMN lesion

  • Symmetrical ascending muscle weakness
  • Autonomic dysfunction - Sweating, tachycardia, Hypertension, arrhythmias

6

 

 

How long does it take for someone to enter the recovery phase of Guillain-Barre syndrome?

 

 

4-6 weeks

7

 

 

What proportion of those with Guillain-Barre syndrome develop respiratory and facial muscle weakness?

 

 

20%

8

 

 

What investigations might you do in someone with suspected Guillain-Barre syndrome?

 

  • Nerve conduction studies
  • LP

9

 

 

What might nerve conduction studies show in someone with Guillain barre syndrome?

 

 

Slow conduction

10

 

 

What might LP investigation show in someone with Guillain-Barre syndrome?

 

  • Increased protein
  • Normal WCC
  • Normal Glucose

11

 

 

What signs may indicate need for transfer to ITU in someone with Guillain-Barre syndrome?

 

 

Respiratory involvement

12

 

 

How would you monitor for respiratory involvement in someone with Guillain-Barre syndrome?

 

 

4-hourly FVC

13

 

 

How would you manage someone with Guillain-Barre Syndrome?

 

  • IVIG - 5 days - 2 weeks
  • DVT prophylaxis - LMWH + compression stockings
  • Consider Plasma exchange

14

 

 

What is the prognosis for someone with Guillain-Barre syndrome?

 

 

Good - 85% of individuals make near/complete recovery. Recovery takes time