Micro: HepaDNAvirus

Question 1

What type of virus is Hepatitis B?

Answer 1

Double stranded circular enveloped DNA virus

Question 2

Hepatitis B capsid shape?

Answer 2

Icosahedral

Question 3

Hepatitis B replicates through a?

Answer 3

RNA reverse transcriptase

Question 4

How is Hep B transmitted?

Answer 4

By all bodily fluids

Question 5

Hep B produces _______ and _________ infections?

Answer 5

Acute and chronic

Question 6

Is Hepatitis B infectious?

Answer 6

Yes, very infectious

Question 7

How is Hep B controlled?

Answer 7

Vaccine

Question 8

Pathogenesis of Hep B?

Answer 8

Infects hepatocytes and produces an X protein which is expressed by infected cells, leading to a cell mediated response of T-cells

Question 9

Resolved hep B infection serology?

Answer 9

Patient will have both HBs and HBc antibodies but no antigen

Question 10

Chronic hep B infection serology?

Answer 10

Patient will have both HBs and HBe antigens, but ONLY HBc antibodies

Question 11

Vaccinated Hep B serology?

Answer 11

A vaccinated patient will have HBs antibodies only

Question 12

During an acute Hepatitis B infection, what antigens are the first indicators in the blood?

Answer 12

HBs antigen and HBe antigen

Question 13

When do HBc antibodies appear in an acute infection of HBV?

Answer 13

Early in the clinical phase

Question 14

When do HBe antibodies appear in an acute infection of HBV?

Answer 14

Early in the clinical phase

Question 15

When do HBs antibodies appear in an acute infection of HBV?

Answer 15

Later, at the beginning of convalescence

Question 16

In acute HBV patients in whom the infection resolves completely, what antibodies are present for life and provide immunity to reinfection?

Answer 16

HBc and HBs antibodies

Question 17

The continued presence of and absence of what two things is an indication that the HBV infection has become chronic?

Answer 17

Continued presence of HBs antigen beyond 6 months and absence of HBs antibodies

Question 18

Incubation period of Hep B?

Answer 18

4-120 days

Question 19

Pre-icteric phase of Hep B shows what signs?

Answer 19

Fever, malaise, nausea

Question 20

Icteric phase of Hep B shows what signs?

Answer 20

Jaundice

Question 21

What group of individuals are most likely to be a carrier of Hep B?

Answer 21

Infants and young children

Question 22

With Hep B, the younger the infected individual, the ________ the risk of chronic infection?

Answer 22

Higher

Question 23

Sequella of Hep B?

Answer 23

Hepatocellular carcinoma and cirrhosis

Question 24

Hepatocellular carcinoma shows a strong association with _______?

Answer 24

HBV

Question 25

The most common natural mode of transmission of infection with hepatitis B virus is via?

Answer 25

Body fluids, such as urine or semen