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Flashcards in Reactions teori Deck (52)
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1

Synthesis of Purine nucleotides (de novo)
- kort forklart

Glucose --> Glucose-6-phosphate --> Ribose-5-phosphate

Ribose-5-phosphate --> 5-phosphoribosyl-1-pyrophosphate (PRPP) --> 5-phosphoribosyl-amine --> Inosine monophosphate (IMP): 2 pathways
--> Adenylosuccinate -> Adenosine diphosphate (ADP): 2 pathways -> Adenosine Triphosphate (ATP)
--> Xanthosine monophosphate -> Guanosine monophosphate (GMP) -> Guanosine diphosphate (GDP) -> Guanosine Triphosphate (GTP)

2

Degradation of purine nucleotides, AMP
- kort fortalt

AMP --> Adenosine, 2pathways:
--> Inosine -> hypoxanthine
--> Adenine -> hypoxanthine
Hypoxanthine --> Xanthine --> Uric Acid --> Allantoine

3

Degradation of purine nucleotides, GMP
- kort fortalt

GMP --> Guanosine --> Guanine --> Xanthine --> Uric Acid --> Allantoine

4

Synthesis of Pyrimidine nucleotides (de novo)
- kort fortalt

HCO3 --> Carbamoyl-P --> N-carbomylaspartate --> Dihydroorotate --> Orotate --> Orotidylate --> Uridine monophosphate (UMP) --> UDP --> UTP --> Cytidinetriphosphate (CTP)

5

Degradation of Pyrimidine nucleotides
- kort fortalt

CMP --> UMP --> Uridine --> Uracil --> Dihydro-uracil --> Ureido-proprionate --> Beta-alanine, 2 pathways:
- > Aceetate
- > HS-CoA

6

Enzyme needed in resynthesis of nucleotides (salvalge pathway) in

1) Each nucleotide
2) Purine nucleotides
a) eukaryotes
b) prokaryotes

1: Nucleoside kinase
2: Adenine-phosphoribosyltransferase
a) Hypoxanthine-guanine-phosphoribosyltransferase (HGPRT)
b) Xanthine-guanine-phosphoribosyltransferase (XGPRT)

7

Synthesis of deoxyribonucleotides
- kort fortalt

ADP, GDP, CDP, UDP --> dADP, dGDP, dCDP, dUDP --> dATP, dGTP, dCTP, dUTP --> dUMP --> dTMP --> dTDP --> dTTP

8

Nucleotide =

base + pentose + phosphate

9

Nucleoside =

base + pentose

10

Pentose =

ribose or (2-)deoxy-ribose

11

Types of Purine bases:

Adenine, guanine

12

Types of Pyrimidine bases:

Cytosine, thymine, uracil

13

Uracil, Thymine and Cytosine bounds to?

Uracil: only ribose
Thymine: only deoxyribose
Cytosine: ribose or deoxyribose

14

Enzyme needed in glucose --> glucose 6-phosphate?

Hexokinase

15

Enzyme needed in ribose 5-phosphate -->5-phosphoribosyl-1-pyrophosphate (PRPP)

PRPP synthetase

16

Enzyme needed in 5-phosphoribosyl-1-pyrophosphate (PRPP) --> 5-phosphoribosyl-amine

PRPP amidotransferase

17

Enzyme needed in Inosine monophosphate (IMP) --> Xanthosine monophosphate

IMP dehydrogenase

18

Enzyme needed in Inosine monophosphate (IMP) --> Adenylosuccinate

Adenylosuccinate synthetase

19

Enzyme needed in Xanthosine monophosphate --> Guanosine monophosphate (GMP)

GMP synthetase

20

Enzyme needed in Adenylosuccinate --> Adenosine monophosphate (AMP)

adenylosucinate lyase

21

Enzyme needed in Guanosine monophosphate (GMP) --> Guanosine diphosphate (GDP) --> guanosine triphosphate (GTP)

1: Nucleotide kinase
2: Nucleoside diphosphate kinase

22

Enzyme needed in adenosine monophosphate (AMP) --> Adenosinde duphosphate (ADP)

Nucleotide kinase

23

reaction needed in Adenosine diphosphate (ADP) --> Adenoisne triphosphate (ATP)

1: Substrate level phosphorylation
2: Oxidative phosphorylation

24

Enzyme needed in AMP --> Adenosine

Nucleotidase

25

Enzyme needed in Adenosine --> inosine

Adenosine deaminase

26

Enzyme needed in Inosine --> hypoxanthine

Nucleoside phosphorylase

27

Enzyme needed in Adenosine --> Adenine

Nucleoside phosphorylase

28

Enzyme needed in Adenine --> Hypoxanthine

Adenine deaminase

29

Enzyme needed in Hypoxanthine --> Xanthine

Xanthine oxidase

30

Enzyme needed in Xanthine --> Uric acid

Xanthine oxidase