Sleep Disorder Treatment Flashcards Preview

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Flashcards in Sleep Disorder Treatment Deck (101)
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1

Goals of Therapy

Promote patient's ability to fall sleep, maintain sleep, & awaken refreshed
Meds as short a time as possible
Use minimal dose with least amount of SE

2

Types of Benzodiazepines

Alprazolam (Xanax)
Estazolam (ProSom)
Flurazepam (Dalmane)
Lorazepam (Ativan)
Quazepam (Doral)
Temazepam (Restoril)
Triazolam (Halcion)

3

MOA of Benzodiazepines

Facilitate the effects of GABA in the ascending reticular activating system

4

Examples of Short Acting Benzodiazepines

Triazolam (Halcion)

5

What are short acting benzodiazepines used for?

Difficulty falling asleep

6

Examples of Intermediate Acting Benzodiazepines

Temazepam (Restoril)
Estazolam (ProSom)

7

What are intermediate acting benzodiazepines used for?

Trouble maintaining or staying asleep

8

Examples of Long Acting Benzodiazepines

Flurazepam (Dalmane)
Quazepam (Doral)

9

What are long acting benzodiazepines used for?

Trouble falling asleep
Maintaining sleep

10

Benzodiazepine SE

Drowsiness
Impaired motor function
Prolonged use can lead to physical dependency
Confusion
Shakiness

11

Interactions with Benzodiazepines

Alcohol
Low-dose contraceptives: benzo's not cleared as quickly

12

Contraindications of Benzodiazepines

Acute narrow-angle glaucoma
Pregnancy
Lactation

13

What were benzodiazepine receptor agonists developed for?

Improve the safety profile of barbiturate-type compounds

14

Half-life of Benzodiazepine Receptor Agonists

5 hours

15

Examples of Benzodiazepine Receptor Agonists

Eszopiclone (Lunesta)
Zolpidem (Ambien)
Zaleplon (Sonata)

16

MOA of Eszopiclone (Lunesta)

Interacts with GABA receptors located near benzodiazepine receptors

17

What affects the absorption of eszopiclone (Lunesta)?

High fat meals

18

When does eszopiclone (Lunesta) peak?

Within 1 hour

19

What is the half-life of eszopiclone (Lunesta)?

5-7 hours

20

Eszopiclone (Lunesta) SE

Headache
Dry mouth
Dizziness
Unpleasant taste in mouth

21

Contraindications for Eszopiclone (Lunesta)

Hypersensitivity

22

Pregnancy Category of Eszopiclone (Lunesta)

Pregnancy C

23

MOA of Zolpidem (Ambien, Ambien CR)

Modulates the GABA receptors to suppress neurons
Sedation & relaxation

24

Who needs a decreased dose of zolpidem (Ambien, Ambien CR)?

Elderly
Women

25

Half-life of Zolpidem (Ambien, Ambien CR)

2.5 hours

26

Onset of Zolpidem (Ambien, Ambien CR)

30 minutes

27

Duration of Zolpidem (Ambien, Ambien CR)

6-8 hours

28

Zolpidem (Ambien, Ambien CR) SE

Morning drowsiness
Hangover effect
Headache
Dizziness
Nausea

29

Contraindications of Zolpidem (Ambien, Ambien CR)

Hypersensitivity

30

Pregnancy Category of Zolpidem (Ambien, Ambien CR)

Pregnancy C