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Flashcards in Sleep Disorder Treatment Deck (101)
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31

MOA of Zaleplon (Sonata)

Interacts with GABA-BZ omega 1 receptor
Sedation
Relaxation
Anti-convulsant activity

32

What is the 2nd line for falling asleep?

Zaleplon (Sonata)

33

Duration of Zaleplon (Sonata)

5 hours

34

Onset of Zleplon (Sonata)

Within 1 hour

35

Half-life of Zaleplon (Sonata)

1 hour

36

Zaleplon (Sonata) SE

Back or chest pain
Migraine
Constipation
Dry mouth
Nervousness

37

Contraindications of Zaleplon (Sonata)

Hypersensitivity

38

Pregnancy Category of Zaleplon (Sonata)

Pregnancy C

39

MOA of Diphenhydramine (Benadryl)

Acts as CNS depressant

40

Contraindications of Diphenhydramine (Benadryl)

Hypersensitivity

41

Pregnancy Category of Diphenhydramine (Benadryl)

Pregnancy B

42

Diphenhydramine (Benadryl) SE

Excessive daytime drowsiness
Impaired psychomotor function
Dry mouth
Delirium
Anti-cholinergic effect
Constipation
Urinary retention

43

Examples of Antidepressants Used for Insomnia

Imipramine (Tofranil)
Amitriptyline hydrochloride (Elavil)
Nortriptyline (Pamelor)

44

Newer Antidepressant Agents

Neazodone hydrochloride (Serzone)
Venlafaxine (Effexor)

45

MOA of Doxepin (Silenor)

Antagonizes histamine receptor
Increases synaptic concentrations of serotonin & norepinephrine in the CNS

46

Doxepin (Silenor) SE

Drowsiness
Dizziness
Constipation
Blurred vision

47

How long after eating does one need to wait to take doxepin (Silenor)?

3 hours

48

Contraindications of Doxepin (Silenor)

Glaucoma
Urinary retention
Constipation

49

Black Box Warning of Doxepin (Silenor)

Suicide thinking/behavior

50

Pregnancy Category of Doxepin (Silenor)

Pregnancy C

51

MOA of Trazodone

Inhibits repute of serotonin
Causes adrenoreceptor subsensitivity
Induces change in 5-HT presynaptic receptor adrenoreceptors
Block histamine receptors

52

Onset of Trazodone

1-3 hours

53

Half-life of Trazodone

7-9 hours
Longer in obese patients

54

Trazodone SE

Dizziness
Drowsiness
Blurred vision
Confusion

55

Contraindications of Trazodone

Use of MAOI's
Patients receiving linezolid or IV methylene blue

56

Pregnancy Category of Trazodone

Pregnancy C

57

Black Box Warning for Trazodone

Suicidal thoughts

58

MOA Amitriptyline (Elavil)

Increases synaptic concentration of serotonin and/or norepinephrine in CNS

59

Half-life of Amitriptyline (Elavil)

13-36 hours

60

Amitriptyline (Elavil) SE

Sedation
Dizziness
Headache
Weight gain
Sexual SE