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Flashcards in Sleep Disorder Treatment Deck (101)
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61

Contraindications of Amitriptyline (Elavil)

Hx of MI
MAOI's

62

Pregnancy Category of Amitriptyline (Elavil)

Pregnancy C

63

Black Box Warning for Amitriptyline (Elavil)

Suicidal thoughts

64

MOA of Ramelteon (Rozerem)

Potent, selective agonist of melatonin receptors MT1 & MT2 within the suprachiasmic nucleus of the hypothalamus

65

Half-life of Ramelteon (Rozerem)

1-2 hours

66

Ramelteon (Rozerem) SE

Somnolence
Headache
Fatigue
Dizziness
Nausea

67

Contraindications for Ramelteon (Rozerem)

Fluvoxamine (Luvox)

68

Pregnancy Category of Ramelteon (Rozerem)

Pregnancy C

69

Melatonin Agonist

Ramelteon (Rozerem)

70

Orexin Receptor Antagonist

Suvorexant (Belsomra)

71

MOA of Suvorexant (Belsomra)

Blocks binding of wake-promoting neuropeptides orexin A & orexin B to receptors OZ1R & OX2R
AKA: Blocks wakening of the patient

72

Duration of Suvorexant (Belsomra)

7 hours

73

When can you not take Suvorexant (Belsomra)?

Immediately after a meal

74

Half-life of Suvorexant (Belsomra)

12 hours

75

Onset of Suvorexant (Belsomra)

30 minutes

76

Suvorexant (Belsomra) SE

Drowsiness
Headache
Abnormal dreams
Lower extremity weakness
Cough

77

Contraindications of Suvorexant (Belsomra)

Narcolepsy

78

Pregnancy Category of Suvorexant (Belsomra)

Pregnancy C

79

Medications for Insomnia

Alprazolam (Xanax)
Estazolam (ProSom)
Flurazepam (Dalmane)
Lorazepam (Ativan)
Quazepam (Doral)
Temazepam (Restoril)
Triazolam (Halcion)
Eszopiclone (Lunesta)
Zolpidem (Ambien)
Zaleplon (Sonata)
Imipramine (Tofranil)
Amitriptyline hydrochloride (Elavil)
Nortriptyline (Pamelor)
Nefazodone hydrochloride (Serzone)
Venlafaxine (Effexor)
Doxepin (Silenor)
Trazodone
Ramelteon (Rozerem)
Suvorexant (Belsomra)

80

First Line Narcolepsy Medication

Modafinil (Provigil)/Armodafinil (Nuvigil)

81

MOA of Modafinil (Provigil)/Armodafinil (Nuvigil)

Not well understood
May increase dopaminergic signaling

82

Modafinil (Provigil)/Armodafinil (Nuvigil) SE

Headache
Nausea
Nervousness
Dry mouth

83

Contraindications of Modafinil (Provigil)/Armodafinil (Nuvigil)

Hypersensitivity

84

Pregnancy Category Modafinil (Provigil)/Armodafinil (Nuvigil)

Pregnancy C

85

Second Line Narcolepsy Medication

Dextroamphetamine

86

MOA of Dextroamphetamine

Not well understood
Stimulates CNS activity
Blocks reuptake & increases release of norepinephrine & dopamine in extra neuronal space

87

Dextroamphetamine SE

HTN
Anorexia
Addiction

88

Pregnancy Category of Dextroamphetamine

Pregnancy C

89

Black Box of Dextroamphetamine

High abuse potential
Cardiac events

90

Medication for REM Sleep Behavior Disorder

Melatonin