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TCA Cycle: Citrate Synthase Flashcards

(8 cards)

1
Q

With what enzyme does the TCA Cycle begin?

A

Citrate synthase

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2
Q

Which enzyme catalyzes the condensation of acetyl-CoA and oxaloacetate?

A

Citrate synthase

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3
Q

Carbons from which types of molecules enter the TCA cycle at citrate synthase?

A

Carbs, fatty acids, and amino acids

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4
Q

True or false: The condensation reaction of acetyl-CoA and oxaloacetate by citrate synthase is ordered sequential, and acetyl Co-A must bind before oxaloacetate.

A

False: The condensation reaction of acetyl-CoA and oxaloacetate by citrate synthase is ordered sequential, and oxaloacetate must bind before acetyl Co-A.

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5
Q

Which molecule must citrate synthase bind first, oxaloaceate or acetyl-CoA?

A

oxaloacetate

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6
Q

What is the structure of citrate synthase?

A

Dimer whose 2 domains form a cleft that contain the oxaloacetate binding site. When oxaloacetate binds, the enzyme’s smaller domain rotates 18 degrees, generating the acetyl-CoA binding site and excluding water.

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7
Q

Is the reaction catalyzed by citrate synthase that forms citrate and CoA exergonic or endergonic?

A

Exergonic

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8
Q

What are the products of the reaction catalyzed by citrate synthase?

A

citrate and CoA

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