Flashcards in Weeks 5 & 6 (Last for Midterm) Deck (17):
Ischemic Heart Disease: Group of syndromes closely related and caused by imbalance myocardial __ demands and __ supply (lack of )2 to myocardium)
What are the 4 pathogenises of Ischemic Heart disease?
Acute changes in heart morphology
Coronary Artery Thrombosis
Coronary Artery Vasospasm
Coronary Artery vasospasm: __ of coronary artery due to __ of the artery AKA __ __- due to release of stress hormones such as __ (seen with __)
What are the 4 forms of Ischmeic Heart Disease?
Sudden Cardiac Death
Chronic Ischemic Heart disease with congestive heart failure
Angina Pectoris: Defined as Intermittent __ pain caused by __ __ __
transient reversible ischemia
Angina Pectoris: causes narrowing of the __ artery of >__% of the lumen
Angina Pectoris: diffuse __ pain due to hypoxia since the blood cannot pump fast enough to get into heart due to narrowing of coronary artery. IS NOT __ PAIN
Angina Pectoris: where does pain radiate too?
Internal portion of arm down to pinkie and also left portion of neck and shooting pain of left scapula
Angina Pectoris: Prinzmetal angina and crescendo angina may also be present. What is crescendo angina?
AKA pre-infarction angina
-steady increase in pain, even when at rest
Acute Myocardial Infarction- #1 killer in USA!! associated with formation of local area of __ due to __- not transient- permanent loss of muscle tissue
Sudden Cardiac Death: 300,000 deatsh in USA per year- 50% of cause of this death is __ problem- death within 24 hrs of problems. 50% of these deaths are due to __ heart disease. Causes are _(3)_
Chronic Ischemic heart disease with Congestive heart failure- Heart muscle doesnt have enough __. Death of __ and there is no regeneration. __ and __ of the myofibrils follows. The __ will develop and leads to __ __ __
congestive heart failure
Congestive Heart disease: Define
Multi-system derangement that occurs when the ehart is no longer able to eject the blood delivered to it by the venous system
Congestive Heart Failure: What are the 3 adaptive responses?
Activity of SNS and overproduction of catecholamines (increase contractility and HR)
Congestive heart failure: Concentric Hypertrophy: Will start if the __ does not work. What is this defined as?
Hypertrophy of heart bc of flow resistance without chamber enlargement
Congestive heart failure: Concentric Hypertrophy: Increased heart demand for O2 but the heart can't supply it. This causes myocardial __