Weeks 5 & 6 (Last for Midterm) Flashcards Preview

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Flashcards in Weeks 5 & 6 (Last for Midterm) Deck (17):
1

Ischemic Heart Disease: Group of syndromes closely related and caused by imbalance myocardial __ demands and __ supply (lack of )2 to myocardium)

02
Blood

2

What are the 4 pathogenises of Ischemic Heart disease?

Acute changes in heart morphology
Platelet Aggregation
Coronary Artery Thrombosis
Coronary Artery Vasospasm

3

Coronary Artery vasospasm: __ of coronary artery due to __ of the artery AKA __ __- due to release of stress hormones such as __ (seen with __)

Stenosis
Spasm
Prinzmetal's Variant
norepinephrine
smoking

4

What are the 4 forms of Ischmeic Heart Disease?

Angina Pectoris
Acute MI
Sudden Cardiac Death
Chronic Ischemic Heart disease with congestive heart failure

5

Angina Pectoris: Defined as Intermittent __ pain caused by __ __ __

chest
transient reversible ischemia

6

Angina Pectoris: causes narrowing of the __ artery of >__% of the lumen

coronary
75

7

Angina Pectoris: diffuse __ pain due to hypoxia since the blood cannot pump fast enough to get into heart due to narrowing of coronary artery. IS NOT __ PAIN

retrosternal
local

8

Angina Pectoris: where does pain radiate too?

Internal portion of arm down to pinkie and also left portion of neck and shooting pain of left scapula

9

Angina Pectoris: Prinzmetal angina and crescendo angina may also be present. What is crescendo angina?

AKA pre-infarction angina
-steady increase in pain, even when at rest

10

Acute Myocardial Infarction- #1 killer in USA!! associated with formation of local area of __ due to __- not transient- permanent loss of muscle tissue

necrosis
Hypoxia

11

Sudden Cardiac Death: 300,000 deatsh in USA per year- 50% of cause of this death is __ problem- death within 24 hrs of problems. 50% of these deaths are due to __ heart disease. Causes are _(3)_

cardiac
ischemic

12

Chronic Ischemic heart disease with Congestive heart failure- Heart muscle doesnt have enough __. Death of __ and there is no regeneration. __ and __ of the myofibrils follows. The __ will develop and leads to __ __ __

oxygen
muscle
Atrophy
necrosis
CT
congestive heart failure

13

Congestive Heart disease: Define

Multi-system derangement that occurs when the ehart is no longer able to eject the blood delivered to it by the venous system

14

Congestive Heart Failure: What are the 3 adaptive responses?

Activity of SNS and overproduction of catecholamines (increase contractility and HR)
Concentric Hypertrophy
Eccentric Hypertrophy

15

Congestive heart failure: Concentric Hypertrophy: Will start if the __ does not work. What is this defined as?

Sympathetics
Hypertrophy of heart bc of flow resistance without chamber enlargement

16

Congestive heart failure: Concentric Hypertrophy: Increased heart demand for O2 but the heart can't supply it. This causes myocardial __

dystrophy

17

Congestive heart failure: Eccentric Hypertrophy: Define

Overload of heart with extra blood. Will cause hypertrophy and enlargement of chambers. Elongation of myofibrils (sterling law) increases contractility