wilsons

Question 1

where is dietary copper absorbed

Answer 1

stomach and upper small intestine

Question 2

how is copper transported

Answer 2

bound to albumin

Question 3

how is copper normally excreted

Answer 3

in bile and faeces

Question 4

what is Wilson’s disease

Answer 4

copper deposition in various organs

Question 5

what type of inheritance is it.

Answer 5

autosomal recessive

Question 6

what chromosome is it on

Answer 6

13

Question 7

what are basal ganglia like.

Answer 7

damaged and show cavitation

Question 8

symptoms

Answer 8

• tremor
• dysarthria
• dementia
• kayser-fleischer ring

Question 9

investigations

Answer 9

• serum copper (reduced)
• liver biopsy
• anaemia
• genetic analysis

Question 10

treatment

Answer 10

penicillamine

Question 11

penicillamine side effects

Answer 11

• skin rashes
• leucopenia
• skin changes
• renal damage

Question 12

if cirrhosis occurs what treatment is given

Answer 12

liver transplant