BL- OSTEOARTHRITIS

Question 1

Osteoarthritis

Answer 1

destruction of articular cartilage

proliferation of contiguous bone

Question 2

Degenerative joint disease

Answer 2

a name for OA

Question 3

degenerative arthritis

Answer 3

a name for OA

Question 4

degenerative arthrosis

Answer 4

is a normal degenerative condition associated with aging. It affects mainly
cartilage which becomes rugged, irregular and worn out.

Question 5

Osteoarthrosis

Answer 5

another name for OA

Question 6

Osteoarthritis Symptoms

Answer 6

Joint pain/inflammation
decreased joint mobility
bony spurs

Question 7

Symptoms of OA

Answer 7

pain with use, improved with rest
stiffness
rarely before 40
lack of systematic symptoms

Question 8

Signs of OA

Answer 8

joint tenderness
bony enlargement
crepitance
swelling

Question 9

Heberden’s and Bouchard’s nodes

Answer 9

Bony enlargement in the inter-phalangeal joint (distal and proximal, respectively)

Question 10

OA deformities

Answer 10

Heberden's and Bouchard's nodes 
Genu Varus
Squaring of the 1st carpometacarpal joint
Hallux valgus
c/l spine spondylosis

Question 11

Genu Varus

Answer 11

bow-legged

Question 12

Hallux Valgus

Answer 12

big toe bunnion

Question 13

spondylosis

Answer 13

Degenerative change

Question 14

In all OA studies, the relationship to_______is striking.

Answer 14

aging

Question 15

Which population has the most severe OA disease

Answer 15

Women. Aging is biggest risk factor

Question 16

Primary OA

Answer 16

no known inciting event

Question 17

Secondary OA

Answer 17

known event or disease caused the OA

Question 18

The joint in OA is grossly characterized by:

Answer 18

cartilage irregularities and “fissuring”

hypertrophy of bone adjacent to the joint

Question 19

Cartiallage consists of:

Answer 19

Collagen 
Proteoglycans
Matrix Proteins
Chrondrocytes
Water

Question 20

Chondrocytes

Answer 20

synthesize extracellualr components

Question 21

Adipokines

Answer 21

cytokine produced by adipose tissue
low grade inflamation
Increases OA risk with obesity

Question 22

Predisposing factors to OA

Answer 22

genetics
metabolic abnormalities
trama
inflammatory joint disease
Obesity 
Age

Question 23

Blood tests for OA

Answer 23

aggrecan, keratin sulfate, and chondroitin sulfate; type II collagen, link protein, and osteocalcin; cartilage matrix glycoprotein, and cartilage oligomeric protein (COMP).

COMP appears the most promising.

Question 24

OA treatment

Answer 24

metalloproteinase inhibitors, synthetic proteoglycans, and intra-articular injection of chelators to inhibit MMP.

Question 25

OA Xray would show

Answer 25

Asymmetric loss of cartilage - Bone touching bone
Bony spurs- prolifferative bone
Subchondral sclerosis

Question 26

Matrix metalloproteinases (MMPs)

Answer 26

collectively cleave most if not all of the constituents of the extracellular matrix.

Question 27

Chondrocytes:

Answer 27

synthesize all of the important extracellular components
Proteoglycan
Collagen